KIF3A Antikörper (AA 485-699)

Produktnummer ABIN4951540

Produktdetails anti-KIF3A Antikörper

Target: KIF3A (Kinesin Family Member 3A (KIF3A))

Bindungsspezifität: AA 485-699

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIF3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: Amino acids 485-699 of human KIF3A were used as the immunogen for the KIF3A antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the KIF3A antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the KIF3A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu KIF3A

Target: KIF3A (Kinesin Family Member 3A (KIF3A))

Andere Bezeichnung: KIF3A (KIF3A Produkte)

Synonyme: FLA10 antikoerper, KLP-20 antikoerper, 111-11-71 antikoerper, 111-11-86 antikoerper, AW124694 antikoerper, Kif3 antikoerper, Kifl antikoerper, Kns3 antikoerper, kinesin family member 3A antikoerper, kinesin family member 3a antikoerper, KIF3A antikoerper, Kif3a antikoerper

Hintergrund: Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene. KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo cytosol using microtubule affinity purification. This motor consists of two kinesin-related subunits (called KIF3A and KIF3B or 3C in vertebrates) and an associated protein (KAP3), and it transports protein complexes, nucleic acids and organelles towards the plus ends of microtubule tracks within cells. Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intra-flagellar transport of tubulins and other axonemal building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips. This process is required for cilium assembly/maintenance and cilium-based signalling which play key roles in various cell and developmental processes. For example, in vertebrate embryos, kinesin-2 function is required for cilia-dependent nodal flow and the development of left-right asymmetry.

UniProt: Q9Y496

Pathways: Hedgehog Signalweg