FGF1 Antikörper

Produktnummer ABIN4951017

Produktdetails anti-FGF1 Antikörper

Target: FGF1 (Fibroblast Growth Factor 1 (Acidic) (FGF1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: Amino acids F16-D155 from the human protein were used as the immunogen for the FGF-1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the FGF-1 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (FFPE): 0.5-1 μg/mL,ELISA: 0.1-0.5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the FGF-1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu FGF1

Target: FGF1 (Fibroblast Growth Factor 1 (Acidic) (FGF1))

Andere Bezeichnung: FGF1 (FGF1 Produkte)

Synonyme: AFGF antikoerper, ECGF antikoerper, ECGF-beta antikoerper, ECGFA antikoerper, ECGFB antikoerper, FGF-1 antikoerper, FGF-alpha antikoerper, FGFA antikoerper, GLIO703 antikoerper, HBGF-1 antikoerper, HBGF1 antikoerper, Fgf1 antikoerper, FGF1 antikoerper, aFGF antikoerper, ecgf antikoerper, fgfa antikoerper, ecgfa antikoerper, ecgfb antikoerper, fgf-1 antikoerper, hbgf1 antikoerper, glio703 antikoerper, ecgf-beta antikoerper, fgf-alpha antikoerper, Dffrx antikoerper, Fam antikoerper, Fgf-1 antikoerper, Fgfa antikoerper, zgc:136885 antikoerper, LOC100221393 antikoerper, fgf1 antikoerper, zgc:73249 antikoerper, fibroblast growth factor 1 antikoerper, fibroblast growth factor 1 L homeolog antikoerper, fibroblast growth factor 1b antikoerper, fibroblast growth factor 1a antikoerper, FGF1 antikoerper, fgf1.L antikoerper, fgf1 antikoerper, Fgf1 antikoerper, fgf1b antikoerper, LOC100221393 antikoerper, fgf1a antikoerper

Hintergrund: Fibroblast growth factor 1 (acidic) plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. [UniProt]

UniProt: P05230

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung