ERBB3 Antikörper (pTyr1328)

Produktnummer ABIN540462

Produktdetails anti-ERBB3 Antikörper

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Bindungsspezifität: pTyr1328

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERBB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit polyclonal antibody raised against synthetic phosphopeptide of ERBB3.

Sequenz: PDYpWH

Spezifität: Her3/ErbB3 (phospho-Tyr1328) Antibody detects endogenous levels of Her3/ErbB3 only when phosphorylated at tyrosine 1328.

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Antibody Reactive Against Synthetic Peptide.

Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y1328 of human ERBB3.

Anwendungsinformationen

Applikationshinweise: Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:100-1:200)
The optimal working dilution should be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: In PBS (without Mg²⁺ and Ca²⁺), 150 mM NaCl, pH 7.4 (50 % glycerol, 0.02 % sodium azide)

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C.
Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-ERBB3 Antikörper (ABIN540462)

Kobayashi, Iwamatsu, Shinohara-Kanda, Ihara, Fukui: "Activation of ErbB3-PI3-kinase pathway is correlated with malignant phenotypes of adenocarcinomas." in: Oncogene, Vol. 22, Issue 9, pp. 1294-301, (2003) (PubMed).

Holbro, Beerli, Maurer, Koziczak, Barbas, Hynes: "The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 15, pp. 8933-8, (2003) (PubMed).

Yarden, Sliwkowski: "Untangling the ErbB signalling network." in: Nature reviews. Molecular cell biology, Vol. 2, Issue 2, pp. 127-37, (2001) (PubMed).

Details zu ERBB3

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Andere Bezeichnung: ERBB3 / HER3 (ERBB3 Produkte)

Gen-ID: 2065

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung