PYCARD Antikörper

Produktnummer ABIN4904914

Produktdetails anti-PYCARD Antikörper

Target: PYCARD (PYD and CARD Domain Containing (PYCARD))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PYCARD Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Produktmerkmale: TMS1 (target of methylation-induced silencing)/ASC (apoptosis-associated speck-like protein containing a CARD), also referred to as PYCARD and CARD5, is a 22- kDa pro-apoptotic protein containing an N-terminal pyrin domain (PYD) and a C-terminal caspase recruitment domain (CARD) (1-2). The TMS1 gene was originally found to be aberrantly methylated and silenced in breast cancer cells (2), and has since been found to be silenced in a number of other cancers, including ovarian cancer (3), glioblastoma (4), melanoma (5), gastric cancer (6), lung cancer (7), and prostate cancer (8). Expression of TMS1 can be induced by pro-apoptotic/inflammatory stimuli (9). During apoptosis TMS1 is re-distributed from the cytosol to the mitochondria and associates with mitochondrial Bax to trigger cytochrome c release and subsequent apoptosis (10). TMS1 has also been found to be a critical component of inflammatory signaling where it associates with and activates caspase-1 in response to pro-inflammatory signals (11).

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human PYCARD.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000 , IHC 1:50-1:200 , IF 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C.

Details zu PYCARD

Target: PYCARD (PYD and CARD Domain Containing (PYCARD))

Andere Bezeichnung: PYCARD (PYCARD Produkte)

Synonyme: ASC antikoerper, CARD5 antikoerper, TMS antikoerper, TMS-1 antikoerper, TMS1 antikoerper, 9130417A21Rik antikoerper, Asc antikoerper, TNS1 antikoerper, masc antikoerper, asc1 antikoerper, zAsc antikoerper, zgc:109874 antikoerper, PYD and CARD domain containing antikoerper, PYCARD antikoerper, Pycard antikoerper, pycard antikoerper

Gen-ID: 29108

UniProt: Q9ULZ3

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation, Inflammasome