LAMB2 Antikörper

Produktnummer ABIN4904193

Produktdetails anti-LAMB2 Antikörper

Target: LAMB2 (Laminin, beta 2 (Laminin S) (LAMB2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LAMB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known.

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human LAMB2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C.

Details zu LAMB2

Target: LAMB2 (Laminin, beta 2 (Laminin S) (LAMB2))

Andere Bezeichnung: LAMB2 (LAMB2 Produkte)

Synonyme: LAMS antikoerper, NPHS5 antikoerper, AW211941 antikoerper, Lamb-2 antikoerper, Lams antikoerper, SLAM antikoerper, lamb1 antikoerper, lams antikoerper, LAMC1 antikoerper, laminin antikoerper, laminin subunit beta 2 antikoerper, laminin, beta 2 antikoerper, laminin subunit beta 2 L homeolog antikoerper, laminin, beta 2 (laminin S) antikoerper, LAMB2 antikoerper, Lamb2 antikoerper, lamb2.L antikoerper

Gen-ID: 3913

UniProt: P55268

Pathways: Skeletal Muscle Fiber Development