MERTK Antikörper (C-Mer Proto-Oncogene Tyrosine Kinase) (AA 26-499)

Details for Product anti-MERTK Antibody No. ABIN4899963, Anbieter: Anmelden zum Anzeigen
Antigen
  • MER
  • RP38
  • c-mer
  • GPR41
  • Gpr30
  • Eyk
  • Mer
  • Nyk
  • nmf12
  • rdy
  • C-EYK
  • MERTK
  • DKFZp469D2215
  • si:ch1073-268l12.2
  • MER proto-oncogene, tyrosine kinase
  • G protein-coupled estrogen receptor 1
  • c-mer proto-oncogene tyrosine kinase
  • c-mer proto-oncogene tyrosine kinase a
  • MERTK
  • Gper1
  • Mertk
  • mertka
Epitop
AA 26-499
37
28
15
9
6
5
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
184
96
53
5
2
2
1
1
1
1
1
Wirt
Ziege
131
34
31
28
Klonalität
Polyklonal
Konjugat
Dieser MERTK Antikörper ist unkonjugiert
13
11
8
8
7
5
5
5
3
3
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS), Western Blotting (WB)
147
105
81
34
33
23
18
17
13
13
3
3
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Mer, Arg26-Ala499, Accession # Q12866
Isotyp IgG
Spezifität Detects human Mer in direct ELISAs and Western blots. In direct ELISAs, approximately 20 % cross-reactivity with recombinant mouse Mer and less than 1 % cross-reactivity with recombinant human (rh) Axl and rhDtk is observed.
Reinigung Antigen Affinity-purified
Sterilität 0.2 μm filtered
Plasmids, Primers & others Plasmide, Primers & weitere MERTK products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Mer (MERTK Antibody Abstract)
Hintergrund Alternative Names: c-Eyk, C-mer, c-mer proto-oncogene tyrosine kinase, EC 2.7.10, EC 2.7.10.1, MER, MER receptor tyrosine kinase, MerTK, MGC133349, Receptor tyrosine kinase MerTK, RP38Proto-oncogene c-Mer, STK kinase, tyrosine-protein kinase Mer
Gen-ID 10461
UniProt Q12866
Pathways RTK Signalweg
Applikations-hinweise Western Blot 1 μg/mL
Flow Cytometry 0.25 μg/10^6 cells
CyTOF-ready
Beschränkungen Nur für Forschungszwecke einsetzbar
Rekonstitution Reconstitute at 0.2 mg/mL in sterile PBS.
Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Konservierungs-mittel Without preservative
Lagerung 4 °C,-20 °C,-80 °C
Informationen zur Lagerung Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 6 months,-20°C to -70°C under sterile conditions after reconstitution.
Haltbarkeit 12 months
Bilder des Herstellers
Western Blotting (WB) image for anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 26-499) antibody (ABIN4899963) Detection of Human Mer by Western Blot. Western blot shows lysates of U937 human hist...
Produkt verwendet in: Richard, Shim, Kwon, Zhang, Otsuka, Schmitt, Berri, Diamond, Choe: "AXL-dependent infection of human fetal endothelial cells distinguishes Zika virus from other pathogenic flaviviruses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 8, pp. 2024-2029, 2017 (PubMed). Von den Autoren verwendete Methode: Neutralization (Neut) (Probematerial (Species): Human).

Cross, Potter, Aldo, Kwon, Pitruzzello, Tong, Guller, Rothlin, Mor, Abrahams: "Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 199, Issue 8, pp. 2885-2895, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Human).

Cai, Thorp, Doran, Subramanian, Sansbury, Lin, Spite, Fredman, Tabas: "MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 23, pp. 6526-31, 2016 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB), Western Blotting (WB) (Probematerial (Species): Human).

Zizzo, Cohen: "IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 10, pp. 5237-46, 2013 (PubMed). Von den Autoren verwendete Methode: Neutralization (Neut) (Probematerial (Species): Human).

Zizzo, Hilliard, Monestier, Cohen: "Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 7, pp. 3508-20, 2012 (PubMed). Von den Autoren verwendete Methode: Neutralization (Neut), Neutralization (Neut) (Probematerial (Species): Human).

Bauer, Zagórska, Jurkin, Yasmin, Köffel, Richter, Gesslbauer, Lemke, Strobl: "Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis." in: The Journal of experimental medicine, Vol. 209, Issue 11, pp. 2033-47, 2012 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB), Western Blotting (WB) (Probematerial (Species): Human).

Eken, Martin, Sadallah, Treves, Schaller, Schifferli: "Ectosomes released by polymorphonuclear neutrophils induce a MerTK-dependent anti-inflammatory pathway in macrophages." in: The Journal of biological chemistry, Vol. 285, Issue 51, pp. 39914-21, 2010 (PubMed). Von den Autoren verwendete Methode: Neutralization (Neut), Neutralization (Neut) (Probematerial (Species): Human).

Uehara, Shacter: "Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 4, pp. 2522-30, 2008 (PubMed). Von den Autoren verwendete Methode: Neutralization (Neut), Neutralization (Neut) (Probematerial (Species): Human).

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