IL2 Antikörper (Interleukin 2) (AA 21-153)

Details for Product anti-IL2 Antibody No. ABIN4899553, Anbieter: Anmelden zum Anzeigen
Antigen
  • IL2
  • IL-2
  • il2
  • TCGF
  • lymphokine
  • Il-2
  • POIL2
  • interleukin 2
  • interleukin-15
  • IL2
  • il2
  • LOC100303688
  • Il2
Epitop
AA 21-153
30
26
19
16
15
15
13
11
11
10
8
4
3
3
3
2
2
2
2
2
1
1
1
Reaktivität
Human
481
247
99
29
17
10
6
6
5
4
3
3
1
1
Wirt
Maus
313
282
210
18
5
4
4
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser IL2 Antikörper ist unkonjugiert
93
50
50
29
28
18
17
14
12
11
9
8
7
7
7
7
7
7
7
6
6
6
4
4
4
4
4
4
4
3
3
2
2
2
1
1
Applikation
Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS), Immunocytochemistry (ICC), Neutralization (Neut)
469
405
224
93
72
50
49
41
41
40
27
26
15
11
11
8
7
7
5
4
4
3
3
2
2
1
1
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Immunogen E. coli-derived recombinant human IL-2, Ala21-Thr153, Accession # NP_000577
Klon 5334
Isotyp IgG1
Spezifität Detects human IL-2 in direct ELISAs. Does not cross-react with recombinant IL-2 from mouse, rat, pig, or cotton rat.
Reinigung Protein A or G purified from hybridoma culture supernatant
Sterilität 0.2 μm filtered
Endotoxin-Niveau <0.10 EU per 1 μg of the antibody by the LAL method.
Andere Bezeichnung IL-2 (IL2 Antibody Abstract)
Hintergrund Alternative Names: aldesleukin, IL2, IL-2lymphokine, interleukin 2, interleukin-2, involved in regulation of T-cell clonal expansion, T cell growth factor, T-cell growth factor, TCGF
Gen-ID 3558
NCBI Accession NP_000577
Pathways JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
Applikationshinweise Neutralization 0.015-0.03 μg/mL
Intracellular Staining by Flow Cytometry 2.5 μg/10^6 cells
Immunocytochemistry 8-25 μg/mL
CyTOF-ready
Beschränkungen Nur für Forschungszwecke einsetzbar
Rekonstitution Reconstitute at 0.5 mg/mL in sterile PBS.
Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Konservierungsmittel Without preservative
Lagerung 4 °C,-20 °C,-80 °C
Informationen zur Lagerung Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 6 months,-20°C to -70°C under sterile conditions after reconstitution.
Haltbarkeit 12 months
Bilder des Herstellers
Neutralization (Neut) image for anti-Interleukin 2 (IL2) (AA 21-153) antibody (ABIN4899553) Cell Proliferation Induced by IL-2 and Neutralization by Human IL-2 Antibody. Recombi...
Immunocytochemistry (ICC) image for anti-Interleukin 2 (IL2) (AA 21-153) antibody (ABIN4899553) IL-2 in Human PBMCs. IL-2 was detected in immersion fixed human peripheral blood mono...
Produkt verwendet in: Locci, Wu, Arumemi, Mikulski, Dahlberg, Miller, Crotty: "Activin A programs the differentiation of human TFH cells." in: Nature immunology, Vol. 17, Issue 8, pp. 976-84, 2016 (PubMed). Von den Autoren verwendete Methode: Biochemical Assay (BCA) (Probematerial (Species): Human).

Jiang, Chen, An, Yang, Zhang, Cheng: "Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling." in: Scientific reports, Vol. 6, pp. 32320, 2016 (PubMed). Von den Autoren verwendete Methode: Flow Cytometry (FACS) (Probematerial (Species): Human).

Nata, Basheer, Cocchi, van Besien, Massoud, Jacobson, Azimi, Tagaya: "Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum." in: The Journal of biological chemistry, Vol. 290, Issue 37, pp. 22338-51, 2015 (PubMed). Von den Autoren verwendete Methode: Neutralization (Neut) (Probematerial (Species): Human).

Weissmüller, Semmler, Kalinke, Christians, Müller-Berghaus, Waibler: "ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation." in: Blood, Vol. 119, Issue 26, pp. 6268-77, 2012 (PubMed). Von den Autoren verwendete Methode: Neutralization (Neut) (Probematerial (Species): Human).

Hutnick, Carnathan, Demers, Makedonas, Ertl, Betts: "Adenovirus-specific human T cells are pervasive, polyfunctional, and cross-reactive." in: Vaccine, Vol. 28, Issue 8, pp. 1932-41, 2010 (PubMed). Von den Autoren verwendete Methode: Flow Cytometry (FACS) (Probematerial (Species): Human).

Withers, Fiorini, Fischer, Ettinger, Lipsky, Grammer: "T cell-dependent survival of CD20+ and CD20- plasma cells in human secondary lymphoid tissue." in: Blood, Vol. 109, Issue 11, pp. 4856-64, 2007 (PubMed). Von den Autoren verwendete Methode: Neutralization (Neut) (Probematerial (Species): Human).

Karenko, Hahtola, Päivinen, Karhu, Syrjä, Kähkönen, Nedoszytko, Kytölä, Zhou, Blazevic, Pesonen, Nevala, Nupponen, Sihto, Krebs, Poustka, Roszkiewicz, Saksela, Peterson, Visakorpi, Ranki: "Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue." in: Cancer research, Vol. 65, Issue 18, pp. 8101-10, 2005 (PubMed). Von den Autoren verwendete Methode: Flow Cytometry (FACS) (Probematerial (Species): Human).

Sen, Chunsong, Baojun, Linjie, Qun, San, Qiuping, Junyan, Zhang, Jinquan: "Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells." in: Immunology, Vol. 112, Issue 2, pp. 274-89, 2004 (PubMed). Von den Autoren verwendete Methode: Flow Cytometry (FACS) (Probematerial (Species): Human).

Herrero, Hu, Li, Samuels, Sharif, Kotenko, Ivashkiv: "Reprogramming of IL-10 activity and signaling by IFN-gamma." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 10, pp. 5034-41, 2003 (PubMed). Von den Autoren verwendete Methode: Neutralization (Neut) (Probematerial (Species): Human).

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