COL1A1 Antikörper (C-Term)

Produktnummer ABIN4886543

Produktdetails anti-COL1A1 Antikörper

Target: COL1A1 (Collagen, Type I, alpha 1 (COL1A1))

Bindungsspezifität: AA 1194-1218, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COL1A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Collagen alpha-1(I) chain(COL1A1) detection. Tested with WB, IHC-P in Human.

Sequenz: AGFDFSFLPQ PPQEKAHDGG RYYRA

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Collagen alpha-1(I) chain(COL1A1) detection. Tested with WB, IHC-P in Human.
Gene Name: collagen, type I, alpha 1
Protein Name: Collagen alpha-1(I) chain

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Collagen I (1194-1218aa AGFDFSFLPQPPQEKAHDGGRYYRA), different from the related mouse and rat sequences by four amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-COL1A1 Antikörper (ABIN4886543)

Tang, Pei, Yang, Wang, Wang, Gao, Li, Yang, Yang: "The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-β1 pathway." in: Scientific reports, Vol. 6, pp. 29975, (2018) (PubMed).

Luo, Li, Liu, Jian, Zou, Zhao, Le, Chen, Gao, He: "Adiponectin Is Involved in Connective Tissue Growth Factor-Induced Proliferation, Migration and Overproduction of the Extracellular Matrix in Keloid Fibroblasts." in: International journal of molecular sciences, Vol. 18, Issue 5, (2018) (PubMed).

Yao, Sun, Fei, Wang, Wang, Zhang, Wu, Liu, Liu, Cui, Li, Yu, Dang, Wang: "Screening in larval zebrafish reveals tissue-specific distribution of fifteen fluorescent compounds." in: Disease models & mechanisms, Vol. 10, Issue 9, pp. 1155-1164, (2018) (PubMed).

Shang, Liu, Liu, Li, Dou, Zhang, Sun, Zhang, Zhu, Mu, Ding, Wen: "Telmisartan improves vascular remodeling through ameliorating prooxidant and profibrotic mechanisms in hypertension via the involvement of transforming growth factor-β1." in: Molecular medicine reports, Vol. 16, Issue 4, pp. 4537-4544, (2018) (PubMed).

Zhou, Zhang, Gao, Tan, Zheng, Zhao, Zhang: "Induced pluripotent stem cell-conditioned medium suppresses pulmonary fibroblast-to-myofibroblast differentiation via the inhibition of TGF-β1/Smad pathway." in: International journal of molecular medicine, Vol. 41, Issue 1, pp. 473-484, (2018) (PubMed).

"Retraction: Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction." in: PLoS ONE, Vol. 13, Issue 2, pp. e0192465, (2018) (PubMed).

Jiang, Zhong, Zheng, Zhao: "Nano-hydroxyapatite/collagen film as a favorable substrate to maintain the phenotype and promote the growth of chondrocytes cultured in vitro." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 2150-2158, (2018) (PubMed).

Zhang, Ju, Nie, Song, Xu, Gao: "Adenovirus‑mediated knockdown of activin A receptor type 2A attenuates immune‑induced hepatic fibrosis in mice and inhibits interleukin‑17‑induced activation of primary hepatic stellate cells." in: International journal of molecular medicine, Vol. 42, Issue 1, pp. 279-289, (2018) (PubMed).

Zhao, Wang, Wang, Hong, Miao, Liao, Zhou, Liu: "An essential role for Wnt/β-catenin signaling in mediating hypertensive heart disease." in: Scientific reports, Vol. 8, Issue 1, pp. 8996, (2018) (PubMed).

Chen, Kong, Liu, Gao, Zhang, Li, Liu: "In vitro differentiation of endometrial regenerative cells into smooth muscle cells: Α potential approach for the management of pelvic organ prolapse." in: International journal of molecular medicine, Vol. 38, Issue 1, pp. 95-104, (2017) (PubMed).

Zhao, Peng, Cui, Guo, Yan: "Dimethyl α-ketoglutarate reduces CCl4-induced liver fibrosis through inhibition of autophagy in hepatic stellate cells." in: Biochemical and biophysical research communications, Vol. 481, Issue 1-2, pp. 90-96, (2017) (PubMed).

Wang, Cao, Liu, Du, Wang, Chen, Liu, Wu: "5-Aminolaevulinic Acid-Based Photodynamic Therapy Restrains Pathological Hyperplasia of Fibroblasts." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 23, pp. 46-56, (2017) (PubMed).

Huang, Jin, Lin, Lin, Zheng, Zhao: "Beneficial effects of sulfonamide‑based gallates on osteoblasts in vitro." in: Molecular medicine reports, Vol. 15, Issue 3, pp. 1149-1156, (2017) (PubMed).

et al.: "Erratum: Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway ..." in: International journal of nanomedicine, Vol. 12, pp. 1515, (2017) (PubMed).

Huang, Wu, Wang, Zheng, Zhao: "Protective effects of baicalin on rabbit articular chondrocytes in vitro." in: Experimental and therapeutic medicine, Vol. 13, Issue 4, pp. 1267-1274, (2017) (PubMed).

Cheng, Ge, Lan, Ma, Chi, Kuang, Sun, Zhao, Liu, Feng, Huang, Luo, Li, Zhang, Hu, Xu, Liu, Huo, Deng, Yang, Xi, Zhang, Siegenthaler, Chen: "Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity." in: Archives of toxicology, Vol. 92, Issue 1, pp. 469-485, (2017) (PubMed).

Wang, Shi, Xu, Qin, Wang: "Hesperetin alleviates renal interstitial fibrosis by inhibiting tubular epithelial-mesenchymal transition in vivo and in vitro." in: Experimental and therapeutic medicine, Vol. 14, Issue 4, pp. 3713-3719, (2017) (PubMed).

Cui, Tang, Li, Wang, Rao, Wang, Liu, Chen: "Lipoxin A4 improves erectile dysfunction in rats with type I diabetes by inhibiting oxidative stress and corporal fibrosis." in: Asian journal of andrology, Vol. 20, Issue 2, pp. 166-172, (2017) (PubMed).

Wang, Yao, Shen, Ding, Shi, Chen, He, Ding, Zhang, Xie: "FOXA2 alleviates CCl4-induced liver fibrosis by protecting hepatocytes in mice." in: Scientific reports, Vol. 7, Issue 1, pp. 15532, (2017) (PubMed).

Zhang, Jin, Tian, Wu: "hsa-miR-29c-3p regulates biological function of colorectal cancer by targeting SPARC." in: Oncotarget, Vol. 8, Issue 61, pp. 104508-104524, (2017) (PubMed).

Details zu COL1A1

Target: COL1A1 (Collagen, Type I, alpha 1 (COL1A1))

Andere Bezeichnung: COL1A1 (COL1A1 Produkte)

Synonyme: OI4 antikoerper, Col1a-1 antikoerper, Cola-1 antikoerper, Cola1 antikoerper, Mov-13 antikoerper, Mov13 antikoerper, COLIA1 antikoerper, col1a1 antikoerper, MGC52532 antikoerper, COL1A1 antikoerper, COL1A2 antikoerper, alpha1(I) antikoerper, cb21 antikoerper, sb:cb21 antikoerper, sb:cb384 antikoerper, wu:fa99c12 antikoerper, wu:fb02c06 antikoerper, alpha3(I) antikoerper, col1a3 antikoerper, hm:zeh0348 antikoerper, wu:fa95h05 antikoerper, wu:fd02a10 antikoerper, wu:fj59a10 antikoerper, collagen type I alpha 1 chain antikoerper, collagen, type I, alpha 1 antikoerper, collagen, type I, alpha 1 S homeolog antikoerper, collagen alpha-1(I) chain antikoerper, collagen type I alpha 2 chain antikoerper, collagen, type I, alpha 1a antikoerper, collagen 1a1 antikoerper, collagen, type I, alpha 1b antikoerper, COL1A1 antikoerper, Col1a1 antikoerper, col1a1.S antikoerper, LOC397571 antikoerper, COL1A2 antikoerper, col1a1a antikoerper, col1a1 antikoerper, col1a1b antikoerper

Hintergrund: Collagen, type I, alpha 1, also known as COL1A1, is a human gene that encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. This gene is mapped to 17q21.33. And this gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis.

Synonyms: Alpha 1 type I collagen | Alpha 2 type I collagen | Alpha-1 type I collagen | CO1A1 | COL1A1 | Collagen alpha-1 chain | Collagen alpha1(I) chain | Collagen alpha-1(I) chain | Collagen I | Collagen Type 1 | Collagen type I alpha 1 | Collagen type I alpha 2 | collagen, type I, alpha 1 | OI4 | Pro alpha 1(I) collagen | Type I procollagen | P02452

Gen-ID: 1277

UniProt: P02452

Pathways: Sensory Perception of Sound, Autophagie, Growth Factor Binding