FBXW7 Antikörper (HRP)

Produktnummer ABIN4880105

Dieses Anti-FBXW7-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von FBXW7 in . Geeignet für Human und Maus.

Kurzübersicht für FBXW7 Antikörper (HRP) (ABIN4880105)

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FBXW7 Antikörper ist konjugiert mit HRP

Applikation: Bitte anfragen

Klon: FBOX 3a9-1

Produktdetails anti-FBXW7 Antikörper (HRP)

Spezifität: This antibody recognises F-box/WD repeat-containing protein 7 (Fbxw7), which is also known as cdc4 and SEL-10. The FBW7/Cdc4 F-box protein was first recognized by its ability to bind cyclin E and the SCF (FBW7) is now known to target c-Myc, c-Jun and Notch for degradation in addition to its role in cyclin E proteolysis. FBW7 negatively regulates several key oncoproteins and is a tumour suppressor that is mutated in a wide spectrum of human cancers.

Aufreinigung: Purified on protein A from tissue culture supernatant.

Immunogen: Synthetic peptide of human sequence

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal antibody dilution should be determined by titration

Kommentare:

Myeloma, fusion partnersCells from immunized mice were fused with the Sp2/0-Ag.14 myeloma cell line

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Purified IgG conjugated to Horseradish Peroxidase using Innova Biosciences Lightning-Link ®, supplied in Phosphate buffered saline (PBS) containing 0.01 % Thiomersal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu FBXW7

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Andere Bezeichnung: Fbxw7/Cdc4

Gen-ID: 55294, 50754

OMIM: 606278

Pathways: Notch Signalweg, EGFR Signaling Pathway