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ENPP3 Antikörper (PE)

ENPP3 Reaktivität: Human FACS, ICC Wirt: Maus Monoclonal NP4D6 PE
Produktnummer ABIN457373
  • Target Alle ENPP3 Antikörper anzeigen
    ENPP3 (Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3))
    Reaktivität
    • 73
    • 35
    • 19
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    Human
    Wirt
    • 53
    • 20
    Maus
    Klonalität
    • 54
    • 19
    Monoklonal
    Konjugat
    • 23
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ENPP3 Antikörper ist konjugiert mit PE
    Applikation
    • 34
    • 26
    • 26
    • 13
    • 13
    • 9
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunocytochemistry (ICC)
    Spezifität
    The mouse monoclonal antibody NP4D6 reacts with an extracellular epitope of CD203c, a transmembrane ectoenzyme expressed on basophils and mast cells, and overexpressed upon their activation.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    HEK-293 cells transfected with human CD203c
    Klon
    NP4D6
    Isotyp
    IgG1
    Top Product
    Discover our top product ENPP3 Primärantikörper
  • Applikationshinweise
    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests. Extracellular and intracellular staining.
    Kommentare

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Heneberg, Riegerová, Kučera: "Pimecrolimus Is a Potent Inhibitor of Allergic Reactions to Hymenopteran Venom Extracts and Birch Pollen Allergen In Vitro." in: PLoS ONE, Vol. 10, Issue 11, pp. e0142953, (2015) (PubMed).

    Platz, Binder, Marxer, Lischka, Valent, Bühring: "Hymenoptera-venom-induced upregulation of the basophil activation marker ecto-nucleotide pyrophosphatase/phosphodiesterase 3 in sensitized individuals." in: International archives of allergy and immunology, Vol. 126, Issue 4, pp. 335-42, (2002) (PubMed).

    Bühring, Seiffert, Giesert, Marxer, Kanz, Valent, Sano: "The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3." in: Blood, Vol. 97, Issue 10, pp. 3303-5, (2001) (PubMed).

    Bühring, Simmons, Pudney, Müller, Jarrossay, van Agthoven, Willheim, Brugger, Valent, Kanz: "The monoclonal antibody 97A6 defines a novel surface antigen expressed on human basophils and their multipotent and unipotent progenitors." in: Blood, Vol. 94, Issue 7, pp. 2343-56, (1999) (PubMed).

  • Target
    ENPP3 (Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3))
    Andere Bezeichnung
    CD203c (ENPP3 Produkte)
    Synonyme
    B10 antikoerper, CD203c antikoerper, NPP3 antikoerper, PD-IBETA antikoerper, PDNP3 antikoerper, Npp3 antikoerper, RB13-6 antikoerper, AI876438 antikoerper, ENPP3 antikoerper, ectonucleotide pyrophosphatase/phosphodiesterase 3 antikoerper, ectonucleotide pyrophosphatase/phosphodiesterase 3 L homeolog antikoerper, ENPP3 antikoerper, Enpp3 antikoerper, enpp3 antikoerper, enpp3.L antikoerper
    Hintergrund
    Ectonucleotide pyrophosphatase/phosphodiesterase 3,CD203c, also known as ENPP-3, is integral membrane ectoenzyme (ectonucleotide pyrophosphatase/phosphodiesterase 3), that hydrolyses nucleotide triphosphates and thus modulates purinergic signaling. CD203c is expressed mainly on activated basophils and mast cells. CD203c is upregulated in response to IgE-receptor cross-linking and is overexpressed on neoplastic mast cells in patients with systemic mastocytosis. Measurement of its induced enhancement on the plasma membrane is useful for diagnostics of allergies.,ENPP3, B10, PDNP3, PD-IBETA
    Gen-ID
    5169
    UniProt
    O14638
    Pathways
    Regulation of Muscle Cell Differentiation, Negative Regulation of Transporter Activity
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