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L-Selectin Antikörper (FITC)

SELL Reaktivität: Maus FACS Wirt: Ratte Monoclonal Mel-14 FITC
Produktnummer ABIN457350
  • Target Alle L-Selectin (SELL) Antikörper anzeigen
    L-Selectin (SELL) (Selectin L (SELL))
    Reaktivität
    • 99
    • 75
    • 41
    • 29
    • 9
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    Maus
    Wirt
    • 96
    • 66
    • 49
    Ratte
    Klonalität
    • 158
    • 48
    • 3
    Monoklonal
    Konjugat
    • 73
    • 27
    • 23
    • 16
    • 13
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser L-Selectin Antikörper ist konjugiert mit FITC
    Applikation
    • 156
    • 56
    • 56
    • 53
    • 35
    • 31
    • 17
    • 13
    • 12
    • 10
    • 8
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The rat monoclonal antibody MEL-14 reacts with an extracellular epitope of murine CD62L (L-selectin), a 75 kDa single chain type I glycoprotein expressed on most peripheral blood B lymphocytes, T lymphocytes, monocytes and granulocytes, it is also present on a subset of NK cells and certain hematopoietic malignant cells.
    Kreuzreaktivität (Details)
    Mouse
    Aufreinigung
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    C3H/eb mouse B cell lymphoma 38C-13
    Klon
    Mel-14
    Isotyp
    IgG2a
    Top Product
    Discover our top product SELL Primärantikörper
  • Applikationshinweise
    Flow cytometry: Recommended dilution: 1 μg/mL.
    Kommentare

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Xu, Manivannan, Crane, Dawson, Liversidge: "Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation." in: Blood, Vol. 112, Issue 4, pp. 1166-74, (2008) (PubMed).

    Pop, Wong, He, Wang, Wallet, Goudy, Tisch: "The type and frequency of immunoregulatory CD4+ T-cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic mice." in: Diabetes, Vol. 56, Issue 5, pp. 1395-402, (2007) (PubMed).

    Richards, Longhi, Wright, Gallimore, Ager: "CD62L (L-selectin) down-regulation does not affect memory T cell distribution but failure to shed compromises anti-viral immunity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 1, pp. 198-206, (2007) (PubMed).

    Chen, Cui, Sempowski, Liu, Chao: "Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease." in: Blood, Vol. 103, Issue 4, pp. 1534-41, (2004) (PubMed).

    Chin, Miller, Graham, Parviz, Zacur, Patel, Duong, Bear: "Bryostatin 1/ionomycin (B/I) ex vivo stimulation preferentially activates L-selectinlow tumor-sensitized lymphocytes." in: International immunology, Vol. 16, Issue 9, pp. 1283-94, (2004) (PubMed).

    Friedline, Wong, Steeber, Tedder, Tisch: "L-selectin is not required for T cell-mediated autoimmune diabetes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 6, pp. 2659-66, (2002) (PubMed).

    Mannering, Cheers: "Interleukin-2 and loss of immunity in experimental Mycobacterium avium infection." in: Infection and immunity, Vol. 70, Issue 1, pp. 27-35, (2001) (PubMed).

    ten Bruggencate, Hillyer, Woodward: "The proportion of CD45RA(+)CD62L(+) (quiescent-phenotype) T cells within the CD8(+) subset increases in advanced weight loss in the protein- or energy-deficient weanling mouse." in: The Journal of nutrition, Vol. 131, Issue 12, pp. 3266-9, (2001) (PubMed).

    Brawand, Cerottini, MacDonald: "Hierarchal utilization of different T-cell receptor Vbeta gene segments in the CD8(+)-T-cell response to an immunodominant Moloney leukemia virus-encoded epitope in vivo." in: Journal of virology, Vol. 73, Issue 11, pp. 9161-9, (1999) (PubMed).

  • Target
    L-Selectin (SELL) (Selectin L (SELL))
    Andere Bezeichnung
    CD62L / L-Selectin (SELL Produkte)
    Synonyme
    CD62L antikoerper, LAM1 antikoerper, LECAM1 antikoerper, LEU8 antikoerper, LNHR antikoerper, LSEL antikoerper, LYAM1 antikoerper, PLNHR antikoerper, TQ1 antikoerper, A.11 antikoerper, L-selectin antikoerper, LECAM-1 antikoerper, SELE antikoerper, AI528707 antikoerper, Lnhr antikoerper, Ly-22 antikoerper, Ly-m22 antikoerper, Lyam-1 antikoerper, Lyam1 antikoerper, selectin L antikoerper, selectin, lymphocyte antikoerper, SELL antikoerper, Sell antikoerper
    Hintergrund
    Selectin L,CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1).,L-selectin, Lsel, Sell, Lam1, Lecam, Leu8, Lnhr, Lyam1, Plnhr
    Gen-ID
    20343
    UniProt
    Q3TCF3
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