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p53 Antikörper (AA 20-31)

TP53 Reaktivität: Human WB, ELISA, IP, IHC (fro), IHC (fp) Wirt: Maus Monoclonal Bp53-11 unconjugated
Produktnummer ABIN4219254
  • Target Alle p53 (TP53) Antikörper anzeigen
    p53 (TP53) (Tumor Protein P53 (TP53))
    Bindungsspezifität
    • 51
    • 41
    • 40
    • 39
    • 32
    • 30
    • 28
    • 25
    • 24
    • 24
    • 23
    • 20
    • 20
    • 20
    • 18
    • 18
    • 16
    • 16
    • 14
    • 13
    • 10
    • 10
    • 9
    • 9
    • 9
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    AA 20-31
    Reaktivität
    • 900
    • 273
    • 223
    • 113
    • 48
    • 35
    • 33
    • 19
    • 10
    • 8
    • 8
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 678
    • 238
    • 6
    • 2
    • 1
    • 1
    Maus
    Klonalität
    • 612
    • 313
    • 1
    Monoklonal
    Konjugat
    • 518
    • 49
    • 40
    • 26
    • 25
    • 25
    • 24
    • 24
    • 23
    • 22
    • 22
    • 13
    • 13
    • 13
    • 13
    • 13
    • 13
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser p53 Antikörper ist unkonjugiert
    Applikation
    • 725
    • 335
    • 257
    • 217
    • 210
    • 151
    • 128
    • 124
    • 119
    • 65
    • 61
    • 35
    • 20
    • 17
    • 13
    • 12
    • 12
    • 10
    • 9
    • 8
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
    Spezifität
    P53
    Kreuzreaktivität
    Human
    Aufreinigung
    Protein A affinity column
    Immunogen
    Recombinant human p53 (transcription domain within the NH2 terminus)
    Klon
    Bp53-11
    Isotyp
    IgG2a
    Top Product
    Discover our top product TP53 Primärantikörper
  • Applikationshinweise
    IHC: 1:500, when using the APAAP method
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    reconstitue with 1 mL deionized water
    Konzentration
    0.025 mg/mL
    Buffer
    PBS, pH 7.4, 0.09 % Sodium azide, 0.5 % BSA
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    2-8°C, extended storage at -20°C, avoid repeated freeze-thaw cycles
  • Zarka, Han, Edelson, Rosenblum: "Expression of cadherins, p53, and BCL2 in small cell carcinomas of the cervix: potential tumor suppressor role for N-cadherin." in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Vol. 13, Issue 2, pp. 240-3, (2003) (PubMed).

    Ohtaké, Cheng, Ida, Suzuki, Ohshiro, Zhang, Saku: "Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry." in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, Vol. 31, Issue 10, pp. 590-7, (2002) (PubMed).

    Homann, Nees, Conradt, Dietz, Weidauer, Maier, Bosch: "Overexpression of p53 in tumor-distant epithelia of head and neck cancer patients is associated with an increased incidence of second primary carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 7, Issue 2, pp. 290-6, (2001) (PubMed).

    Andl, Kahn, Pfuhl, Nicola, Erber, Conradt, Klein, Helbig, Dietz, Weidauer, Bosch: "Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control." in: Cancer research, Vol. 58, Issue 1, pp. 5-13, (1998) (PubMed).

    Petersen, Song, Hügle-Dörr, Oldenburg, Bautz: "Mapping of linear epitopes recognized by monoclonal antibodies with gene-fragment phage display libraries." in: Molecular & general genetics : MGG, Vol. 249, Issue 4, pp. 425-31, (1996) (PubMed).

    Stephen, Helminen, Lane: "Characterisation of epitopes on human p53 using phage-displayed peptide libraries: insights into antibody-peptide interactions." in: Journal of molecular biology, Vol. 248, Issue 1, pp. 58-78, (1995) (PubMed).

    Fisher, Gillett, Vojtĕsek, Barnes, Millis: "Problems with p53 immunohistochemical staining: the effect of fixation and variation in the methods of evaluation." in: British journal of cancer, Vol. 69, Issue 1, pp. 26-31, (1994) (PubMed).

    Bártek, Bártková, Lukás, Stasková, Vojt?sek, Lane: "Immunohistochemical analysis of the p53 oncoprotein on paraffin sections using a series of novel monoclonal antibodies." in: The Journal of pathology, Vol. 169, Issue 1, pp. 27-34, (1993) (PubMed).

    Bártek, Bártková, Vojtĕsek, Stasková, Rejthar, Kovarík, Lane: "Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro." in: International journal of cancer, Vol. 46, Issue 5, pp. 839-44, (1990) (PubMed).

  • Target
    p53 (TP53) (Tumor Protein P53 (TP53))
    Andere Bezeichnung
    P53 (TP53 Produkte)
    Synonyme
    BCC7 antikoerper, LFS1 antikoerper, P53 antikoerper, TRP53 antikoerper, p53 antikoerper, Trp53 antikoerper, brp53 antikoerper, drp53 antikoerper, etID22686.5 antikoerper, fb40d06 antikoerper, wu:fb40d06 antikoerper, zgc:111919 antikoerper, Tp53 antikoerper, bbl antikoerper, bfy antikoerper, bhy antikoerper, p44 antikoerper, tp53 antikoerper, Xp53 antikoerper, TP53 antikoerper, tumor protein p53 antikoerper, cellular tumor antigen p53 antikoerper, transformation related protein 53 antikoerper, tumor protein p53 L homeolog antikoerper, TP53 antikoerper, CpipJ_CPIJ002758 antikoerper, Tp53 antikoerper, tp53 antikoerper, Trp53 antikoerper, tp53.L antikoerper
    Hintergrund
    Excellent marker for wild-type and mutant forms of human p53 antigen. The antibody stains positively approx. 60 % of investigated carcinoma of lung, breast, colon, stomach, esophagus, pancreas, urinary bladder and testis, head and neck tumors, T-cell Leuk
    Gen-ID
    7157
    UniProt
    P04637
    Pathways
    p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt
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