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TRKA Antikörper (pSer791)

NTRK1 Reaktivität: Human IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN401580
  • Target Alle TRKA (NTRK1) Antikörper anzeigen
    TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
    Bindungsspezifität
    • 36
    • 26
    • 25
    • 19
    • 16
    • 15
    • 15
    • 10
    • 10
    • 9
    • 8
    • 8
    • 8
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer791
    Reaktivität
    • 239
    • 151
    • 144
    • 15
    • 4
    • 4
    • 1
    • 1
    Human
    Wirt
    • 248
    • 15
    • 3
    • 2
    Kaninchen
    Klonalität
    • 240
    • 27
    • 1
    Polyklonal
    Konjugat
    • 102
    • 18
    • 15
    • 13
    • 11
    • 11
    • 11
    • 11
    • 11
    • 11
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TRKA Antikörper ist unkonjugiert
    Applikation
    • 185
    • 99
    • 79
    • 78
    • 51
    • 38
    • 30
    • 20
    • 19
    • 14
    • 8
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Immunofluorescence (IF)
    Spezifität
    Antibody AP09480PU detects endogenous levels of TrkA only when phosphorylated at Tyrosine 791.
    Aufreinigung
    Immunoaffinity Chromatography using epitope-specific phosphopeptide.
    Immunogen
    The antiserum was produced against synthesized phosphopeptide derived from human TrkA around the phosphorylation site of tyrosine791 (P-V-Yp-L-D).
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    Discover our top product NTRK1 Primärantikörper
  • Applikationshinweise
    Immunofluorescence: 1/100approx. 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at-20 °C.
  • Target
    TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
    Andere Bezeichnung
    TrkA (NTRK1 Produkte)
    Synonyme
    MTC antikoerper, TRK antikoerper, TRK1 antikoerper, TRKA antikoerper, Trk-A antikoerper, p140-TrkA antikoerper, CDHF12 antikoerper, CDHR16 antikoerper, HSCR1 antikoerper, MEN2A antikoerper, MEN2B antikoerper, MTC1 antikoerper, PTC antikoerper, RET-ELE1 antikoerper, RET51 antikoerper, Trk antikoerper, C80751 antikoerper, Tkr antikoerper, TrkA antikoerper, trk antikoerper, trka antikoerper, CTRKA antikoerper, trkA antikoerper, neurotrophic receptor tyrosine kinase 1 antikoerper, ret proto-oncogene antikoerper, neurotrophic tyrosine kinase, receptor, type 1 antikoerper, NTRK1 antikoerper, RET antikoerper, Ntrk1 antikoerper, ntrk1 antikoerper
    Hintergrund
    The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins. Phosphorylation at Tyr490 is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth. Phosphorylations at Tyr674 and Tyr675 lie within the catalytic domain of TrkA tyrosine kinase and reflect Trk kinase activity. Additionally, phosphorylation at Tyr751 is required for PI3-kinase association and activation of the Akt signaling cascade.Synonyms: High affinity nerve growth factor receptor, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1-transforming tyrosine kinase protein, Trk-A, p140-TrkA
    Gen-ID
    4914
    NCBI Accession
    NP_001007793
    UniProt
    P04629
    Pathways
    RTK Signalweg, Neurotrophin Signalübertragung, cAMP Metabolic Process
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