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MTOR Antikörper (AA 2440-2457)

mTOR Reaktivität: Human, Maus, Hund, Zebrafisch (Danio rerio) WB, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN401320
  • Target Alle MTOR (mTOR) Antikörper anzeigen
    MTOR (mTOR) (Mechanistic Target of Rapamycin (serine/threonine Kinase) (mTOR))
    Bindungsspezifität
    • 34
    • 28
    • 23
    • 15
    • 12
    • 11
    • 9
    • 7
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2440-2457
    Reaktivität
    • 214
    • 140
    • 121
    • 23
    • 17
    • 12
    • 7
    • 6
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Hund, Zebrafisch (Danio rerio)
    Wirt
    • 194
    • 16
    • 2
    • 2
    Kaninchen
    Klonalität
    • 174
    • 39
    Polyklonal
    Konjugat
    • 110
    • 11
    • 10
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MTOR Antikörper ist unkonjugiert
    Applikation
    • 148
    • 65
    • 63
    • 52
    • 52
    • 44
    • 36
    • 36
    • 17
    • 17
    • 12
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Spezifität
    Reactivity occurs with both phosphorylated and non-phosphorylated forms of mTOR at S2448 from derived tissues and cells.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Rat, Mouse, Zebrafish, Canine.
    Species reactivity (tested):Human.
    Aufreinigung
    Immunoaffinity chromatography
    Immunogen
    Synthetic peptide corresponding to amino acids 2440-2457 of human mTOR
    Isotyp
    IgG
    Top Product
    Discover our top product mTOR Primärantikörper
  • Applikationshinweise
    ELISA: 1/4000 - 1/20000. Western Blot: 1/250 - 1/2000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.40 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
  • Target
    MTOR (mTOR) (Mechanistic Target of Rapamycin (serine/threonine Kinase) (mTOR))
    Andere Bezeichnung
    mTOR / FRAP1 (mTOR Produkte)
    Synonyme
    FRAP1 antikoerper, FRAP antikoerper, FRAP2 antikoerper, RAFT1 antikoerper, RAPT1 antikoerper, 2610315D21Rik antikoerper, AI327068 antikoerper, Frap1 antikoerper, flat antikoerper, frap1 antikoerper, tor antikoerper, wu:fc22h08 antikoerper, mechanistic target of rapamycin kinase antikoerper, mechanistic target of rapamycin antikoerper, mechanistic target of rapamycin (serine/threonine kinase) antikoerper, MTOR antikoerper, Mtor antikoerper, mtor antikoerper
    Hintergrund
    Mammalian target of rapamycin (mTOR) is a serine and threonine protein kinase that regulates numerous cellular functions, in particular, the initiation of protein translation. Rapamycin is a natural product macrolide that induces G1 growth arrest in yeast, Drosophila, and mammalian cells. mTOR has a long list of synonyms including FK506 binding protein12 - rapamycin associated protein 1, FK506 binding protein12 - rapamycin associated protein 2, FRAP1, FRAP2, RAFT1, RAPT1 and/or FKBP12-rapamycin associated protein (FRAP). mTOR is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, mTOR is a 245-kD protein referred to as RAFT1 with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of mTOR to FKBP12-rapamycin correlates with the ability of these ligands to inhibit cell cycle progression.Synonyms: FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, FRAP, FRAP2, Mammalian target of rapamycin, RAPT1, Rapamycin target protein, Serine/threonine-protein kinase mTOR, TOR
    Gen-ID
    2475
    NCBI Accession
    NP_004949
    UniProt
    P42345
    Pathways
    PI3K-Akt Signalweg, RTK Signalweg, AMPK Signaling, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagie, CXCR4-mediated Signaling Events, BCR Signaling, Warburg Effekt
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