Arrestin 3 Antikörper (Arrestin, beta 2) (AA 300-410)

Details for Product anti-ARRB2 Antibody No. ABIN393334, Anbieter: Anmelden zum Anzeigen
Antigen
  • ARRB2
  • arb2
  • arr2
  • arrestin
  • barr2
  • betaarr2
  • ARB2
  • ARR2
  • BARR2
  • BARRES
  • AI326910
  • AW122872
  • arrb2
  • zgc:64007
  • arrestin beta 2
  • arrestin, beta 2
  • arrestin beta 2 L homeolog
  • arrestin, beta 2b
  • ARRB2
  • arrb2
  • Arrb2
  • arrb2.L
  • arrb2b
Epitop
AA 300-410
13
7
7
5
4
4
3
3
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human
97
34
30
8
7
6
5
5
3
2
2
2
1
1
1
1
Wirt
Maus
61
23
13
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser Arrestin 3 Antikörper ist unkonjugiert
5
3
2
1
1
1
Applikation
ELISA, Immunofluorescence (IF), Western Blotting (WB)
84
55
42
28
23
19
5
3
2
2
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Immunogen

Antigen Type: Recombinant Protein

Target/Specificity: ARRB2 (AAH07427, 300 a.a. ~ 409 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Klon 3G1
Isotyp IgG2a kappa
Spezifität ARRB2 (AAH07427, 300 a.a. ~ 410 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Kreuzreaktivität (Details) Human: ~~ Positive
Reinigung This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Plasmids, Primers & others Plasmide, Primers & weitere Arrestin 3 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung ARRB2 (ARRB2 Antibody Abstract)
Hintergrund

Other Names: Beta-arrestin-2, Arrestin beta-2, ARRB2, ARB2, ARR2

Gene Description: arrestin, beta 2

Gene Summary: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq

Molekulargewicht 46106 DA
Gen-ID 409
NCBI Accession NP_001244257, NP_001244258, NP_001244259, NP_001244260, NP_004304, NP_945355
UniProt P32121
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Phototransduction, Thromboxane A2 Receptor Signaling
Applikations-hinweise Western blot = 1:500-1000
Kommentare

Background: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

Beschränkungen Nur für Forschungszwecke einsetzbar
Buffer Clear, colorless solution in phosphate buffered saline,  pH 7.2 .
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Haltbarkeit 6 months
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Arrestin, beta 2 (ARRB2) (AA 300-410) antibody (ABIN393334) anti-Arrestin, beta 2 (ARRB2) (AA 300-410) antibody
Western Blotting (WB) image for anti-Arrestin, beta 2 (ARRB2) (AA 300-410) antibody (ABIN393334) Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunoge...
Western Blotting (WB) image for anti-Arrestin, beta 2 (ARRB2) (AA 300-410) antibody (ABIN393334) Western Blot analysis of ARRB2 expression in transfected 293T cell line by ARRB2 mono...
Immunofluorescence (IF) image for anti-Arrestin, beta 2 (ARRB2) (AA 300-410) antibody (ABIN393334) Immunofluorescence of monoclonal antibody to ARRB2 on HeLa cell . [antibody concentra...
ELISA image for anti-Arrestin, beta 2 (ARRB2) (AA 300-410) antibody (ABIN393334) Detection limit for recombinant GST tagged ARRB2 is approximately 0.03ng/ml as a capt...
 image for anti-Arrestin, beta 2 (ARRB2) (AA 300-410) antibody (ABIN393334) Proximity Ligation Analysis of protein-protein interactions between MAPK3 and ARRB2. ...
Allgemeine Veröffentlichungen Oneda, Crettol, Bochud, Besson, Croquette-Krokar, Hämmig, Monnat, Preisig, Eap: "β-Arrestin2 influences the response to methadone in opioid-dependent patients." in: The pharmacogenomics journal, Vol. 11, Issue 4, pp. 258-66, 2011 (PubMed).

Li, Sun, LeSage, Zhang, Liang, Chen, Hanley, He, Sun, Yin: "β-arrestin 2 regulates Toll-like receptor 4-mediated apoptotic signalling through glycogen synthase kinase-3β." in: Immunology, Vol. 130, Issue 4, pp. 556-63, 2010 (PubMed).

Bousman, Glatt, Cherner, Atkinson, Grant, Tsuang, Everall,: "Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependence." in: Psychiatry research, Vol. 178, Issue 2, pp. 295-8, 2010 (PubMed).

Kuhr, Zhang, Brovkovych, Skidgel: "Beta-arrestin 2 is required for B1 receptor-dependent post-translational activation of inducible nitric oxide synthase." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 7, pp. 2475-83, 2010 (PubMed).

Shankar, Michal, Kern, Kang, Gurevich, Benovic: "Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function." in: The Journal of biological chemistry, Vol. 285, Issue 11, pp. 8316-29, 2010 (PubMed).

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