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NEK9 Antikörper (C-Term)

NEK9 Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal RB2989 unconjugated
Produktnummer ABIN392654
  • Target Alle NEK9 Antikörper anzeigen
    NEK9 (NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9))
    Bindungsspezifität
    • 10
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 846-877, C-Term
    Reaktivität
    • 77
    • 50
    • 27
    • 6
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus
    Wirt
    • 73
    • 4
    Kaninchen
    Klonalität
    • 76
    • 1
    Polyklonal
    Konjugat
    • 32
    • 7
    • 7
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NEK9 Antikörper ist unkonjugiert
    Applikation
    • 61
    • 38
    • 20
    • 13
    • 10
    • 7
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This NEK9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 846-877 amino acids from the C-terminal region of human NEK9.
    Klon
    RB2989
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product NEK9 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    NEK9 (NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9))
    Andere Bezeichnung
    NEK9 (NEK9 Produkte)
    Synonyme
    NERCC antikoerper, NERCC1 antikoerper, Nek8 antikoerper, NEK9 antikoerper, nercc antikoerper, nercc1 antikoerper, C130021H08Rik antikoerper, NIMA related kinase 9 antikoerper, NIMA-related kinase 9 antikoerper, NIMA related kinase 8 antikoerper, NIMA (never in mitosis gene a)-related expressed kinase 9 antikoerper, NIMA-related kinase 9 L homeolog antikoerper, NEK9 antikoerper, nek9 antikoerper, NEK8 antikoerper, Nek9 antikoerper, nek9.L antikoerper
    Hintergrund
    NEK9, a member of the NIMA subfamily of Ser/Thr protein kinases, is a pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. It phosphorylates different histones (serine and threonine residues on H3), myelin basic protein, beta-casein (serine residues), and BICD2. NEK9 is activated during mitosis by intramolecular autophosphorylation. Activity and autophosphorylation is activated by manganese >> magnesium ions, and is sensitive to increasing concentration of detergents. This protein is not cell-cycle regulated but activity is higher in G0-arrested cells. NEK is part of a homodimer that binds to Ran GTPase, and exhibits a greater affinity for Ran-GDP over Ran-GTP. Interaction is also noted with NEK6 and NEK7 family members. This cytoplasmic protein is most abundant in heart, liver, kidney and testis, and is also expressed in smooth muscle cells and fibroblasts. Expression varies mildly across the cell cycle, with highest expression observed in G1 and stationary-phase cells.
    Molekulargewicht
    107168
    Gen-ID
    91754
    NCBI Accession
    NP_149107
    UniProt
    Q8TD19
    Pathways
    SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion
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