Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Aufreinigung
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This TRPM6 (CHAK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-348 amino acids from the Central region of human TRPM6 (CHAK2).
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit
6 months
Furukawa, Fujii, Manabe, Matsunaga, Endo, Hasegawa, Ito, Yamaguchi, Yamazaki, Ikari: "Up-Regulation of Transient Receptor Potential Melastatin 6 Channel Expression by Tumor Necrosis Factor-α in the Presence of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor." in: Journal of cellular physiology, Vol. 232, Issue 10, pp. 2841-2850, (2017) (PubMed).
Ikari, Okude, Sawada, Takahashi, Sugatani, Miwa: "Down-regulation of TRPM6-mediated magnesium influx by cyclosporin A." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 377, Issue 4-6, pp. 333-43, (2008) (PubMed).
Ikari, Okude, Sawada, Yamazaki, Sugatani, Miwa: "TRPM6 expression and cell proliferation are up-regulated by phosphorylation of ERK1/2 in renal epithelial cells." in: Biochemical and biophysical research communications, Vol. 369, Issue 4, pp. 1129-33, (2008) (PubMed).
Target
TRPM6
(Transient Receptor Potential Cation Channel, Subfamily M, Member 6 (TRPM6))
TRPM6 antikoerper, CHAK2 antikoerper, HMGX antikoerper, HOMG antikoerper, HOMG1 antikoerper, HSH antikoerper, TRPM6/CHAK2 antikoerper, transient receptor potential cation channel subfamily M member 6 antikoerper, transient receptor potential cation channel, subfamily M, member 6 antikoerper, TRPM6 antikoerper, Trpm6 antikoerper
Hintergrund
CHAK2 is a member of the ion channel proteins. It regulates the calcium concentration in cells, which is imperative for such functions as muscle contractions and neuronal firing. It is also upregulated in certain forms of cancer and could play a role in diabetes.