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DCLK1 Antikörper (AA 690-720)

DCLK1 Reaktivität: Human, Maus, Ratte WB Wirt: Kaninchen Polyclonal RB3161 unconjugated
Produktnummer ABIN391324
  • Target Alle DCLK1 Antikörper anzeigen
    DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))
    Bindungsspezifität
    • 16
    • 15
    • 9
    • 8
    • 7
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 690-720
    Reaktivität
    • 85
    • 45
    • 12
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 84
    • 6
    • 1
    Kaninchen
    Klonalität
    • 76
    • 15
    Polyklonal
    Konjugat
    • 34
    • 9
    • 8
    • 7
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DCLK1 Antikörper ist unkonjugiert
    Applikation
    • 72
    • 43
    • 20
    • 17
    • 13
    • 13
    • 9
    • 9
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This DCAMKL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 690-720 amino acids of human DCAMKL1.
    Klon
    RB3161
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product DCLK1 Primärantikörper
  • Applikationshinweise
    WB: 1:2000. WB: 1:1000. WB: 1:8000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid freeze-thaw cycles.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    Haltbarkeit
    6 months
  • Kawamura, Takemoto, Nishimoto, Ueno, Hosoyama, Shirasawa, Tanaka, Kugimiya, Harada, Hamano: "Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells." in: Oncology reports, Vol. 38, Issue 5, pp. 3238-3244, (2018) (PubMed).

    Ushiama, Ishimaru, Narukawa, Yoshioka, Kozuka, Watanabe, Tsunoda, Osakabe, Asakura, Masuzaki, Abe: "Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice." in: EBioMedicine, Vol. 8, pp. 60-71, (2017) (PubMed).

    Gao, Wang, Xu, Wen, Liu, An: "DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer." in: Journal of cancer research and clinical oncology, Vol. 142, Issue 10, pp. 2131-40, (2017) (PubMed).

    Leppänen, Helminen, Huhta, Kauppila, Miinalainen, Ronkainen, Saarnio, Lehenkari, Karttunen: "Doublecortin-like kinase 1-positive enterocyte - a new cell type in human intestine." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 124, Issue 11, pp. 958-965, (2017) (PubMed).

    Schellnegger, Quante, Rospleszcz, Schernhammer, Höhl, Tobiasch, Pastula, Brandtner, Abrams, Strauch, Schmid, Vieth, Wang, Quante: "Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma." in: Cancer prevention research (Philadelphia, Pa.), Vol. 10, Issue 1, pp. 55-66, (2017) (PubMed).

    Nakata, Shimizu, Nagata, Ito, Fujii, Suzuki, Kawamoto, Ishibashi, Kuno, Anzai, Murano, Mizutani, Oshima, Tsuchiya, Nakamura, Hozumi, Watanabe, Okamoto: "Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine." in: Data in brief, Vol. 10, pp. 551-556, (2017) (PubMed).

    Gross, Balderes, Liu, Asfaha, Gu, Wang, Sussel: "Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential." in: American journal of physiology. Gastrointestinal and liver physiology, pp. ajpgi.00244.2015, (2015) (PubMed).

    Shimizu, Okamoto, Ito, Fujii, Nakata, Suzuki, Murano, Mizutani, Tsuchiya, Nakamura, Hozumi, Watanabe: "Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine." in: PeerJ, Vol. 2, pp. e370, (2014) (PubMed).

    Gonzalez, Williamson, Piedrahita, Blikslager, Magness: "Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration." in: PLoS ONE, Vol. 8, Issue 6, pp. e66465, (2013) (PubMed).

    Trivedi, Wiber, El-Zimaity, Brubaker: "Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 302, Issue 8, pp. G840-9, (2012) (PubMed).

    Yu, Chen, Zhang, Li, Xu, Wang, Ai, Liu: "Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity." in: PLoS ONE, Vol. 7, Issue 2, pp. e32492, (2012) (PubMed).

    Gerbe, van Es, Makrini, Brulin, Mellitzer, Robine, Romagnolo, Shroyer, Bourgaux, Pignodel, Clevers, Jay: "Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium." in: The Journal of cell biology, Vol. 192, Issue 5, pp. 767-80, (2011) (PubMed).

    Gerbe, Brulin, Makrini, Legraverend, Jay: "DCAMKL-1 expression identifies Tuft cells rather than stem cells in the adult mouse intestinal epithelium." in: Gastroenterology, Vol. 137, Issue 6, pp. 2179-80; author reply 2180-1, (2009) (PubMed).

    Dekaney, Gulati, Garrison, Helmrath, Henning: "Regeneration of intestinal stem/progenitor cells following doxorubicin treatment of mice." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 297, Issue 3, pp. G461-70, (2009) (PubMed).

    May, Riehl, Hunt, Sureban, Anant, Houchen et al.: "Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple ..." in: Stem cells (Dayton, Ohio), Vol. 26, Issue 3, pp. 630-7, (2008) (PubMed).

  • Target
    DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))
    Andere Bezeichnung
    DCAMKL1 (DCLK1 Produkte)
    Synonyme
    DCLK1 antikoerper, DCAMKL1 antikoerper, dcamkl1 antikoerper, dclk1 antikoerper, wu:fc51f11 antikoerper, zgc:153709 antikoerper, MGC145348 antikoerper, CL1 antikoerper, CLICK1 antikoerper, DCDC3A antikoerper, DCLK antikoerper, 1700113D08Rik antikoerper, 2810480F11Rik antikoerper, AI836758 antikoerper, Click-I antikoerper, Cpg16 antikoerper, Dcamkl1 antikoerper, Dcl antikoerper, Dclk antikoerper, mKIAA0369 antikoerper, Ania4 antikoerper, doublecortin like kinase 1 antikoerper, doublecortin-like kinase 1a antikoerper, serine/threonine-protein kinase DCLK1 antikoerper, doublecortin-like kinase 2 antikoerper, doublecortin-like kinase 1 antikoerper, DCLK1 antikoerper, dclk1a antikoerper, LOC587664 antikoerper, dclk2 antikoerper, LOC100539645 antikoerper, Dclk1 antikoerper
    Hintergrund
    Doublecortin-like kinase (DCAMKL1)(Ser/Thr protein kinase family) is essential for proper neurogenesis, neuronal migration, and axonal wiring. DCAMKL1 is involved in a calcium-signaling pathway controling neuronal migration in the developing brain, and participates in functions of the mature nervous system. DCAMKL1 protein shares high homology with doublecortin (DCX). DCLK, but not DCX, is highly expressed in regions of active neurogenesis in the neocortex and cerebellum. DCAMKL1 controls mitotic division by regulating spindle formation and also determines the fate of neural progenitors during cortical neurogenesis.
    Molekulargewicht
    82224
    Gen-ID
    9201
    NCBI Accession
    NP_001182344, NP_001182345, NP_004725
    UniProt
    O15075
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