ACVR1C/ALK7 Antikörper (N-Term)

Produktnummer ABIN391157

Produktdetails anti-ACVR1C/ALK7 Antikörper

Target: ACVR1C/ALK7 (ACVR1C) (Activin Receptor Type 1C (ACVR1C))

Bindungsspezifität: AA 33-62, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ACVR1C/ALK7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: M

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Activin A Receptor Type IC (ACVR1C) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human Activin A Receptor Type IC (ACVR1C).

Klon: RB8195

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-ACVR1C/ALK7 Antikörper (ABIN391157)

Liu, Yang, Li, Liu, Miao, Yang, Zou, Yuan: "Overexpression of B2M and loss of ALK7 expression are associated with invasion, metastasis, and poor-prognosis of the pancreatic ductal adenocarcinoma." in: Cancer biomarkers : section A of Disease markers, Vol. 15, Issue 6, pp. 735-43, (2015) (PubMed).

Details zu ACVR1C/ALK7

Target: ACVR1C/ALK7 (ACVR1C) (Activin Receptor Type 1C (ACVR1C))

Andere Bezeichnung: Activin A Receptor Type IC (ACVR1C) (ACVR1C Produkte)

Synonyme: ACVRLK7 antikoerper, ALK7 antikoerper, Alk-7 antikoerper, C230097P10 antikoerper, Alk7 antikoerper, habrec1 antikoerper, activin A receptor type 1C antikoerper, activin A receptor, type IC antikoerper, ACVR1C antikoerper, Acvr1c antikoerper

Hintergrund: ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.

Molekulargewicht: 54871

Gen-ID: 130399

NCBI Accession: NP_001104501, NP_001104502, NP_001104503, NP_660302

UniProt: Q8NER5

Pathways: Negative Regulation of Hormone Secretion, Positive Regulation of Endopeptidase Activity