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CDC25A Antikörper (pThr507)

CDC25A Reaktivität: Human WB, IHC (p), IF Wirt: Kaninchen Polyclonal RB7856 unconjugated
Produktnummer ABIN389532
  • Target Alle CDC25A Antikörper anzeigen
    CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))
    Bindungsspezifität
    • 34
    • 32
    • 21
    • 17
    • 15
    • 12
    • 9
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 480-514, pThr507
    Reaktivität
    • 234
    • 93
    • 77
    • 5
    • 4
    • 4
    • 4
    • 4
    • 2
    Human
    Wirt
    • 243
    • 7
    Kaninchen
    Klonalität
    • 244
    • 6
    Polyklonal
    Konjugat
    • 107
    • 21
    • 16
    • 15
    • 11
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 3
    • 3
    • 3
    • 3
    • 3
    Dieser CDC25A Antikörper ist unkonjugiert
    Applikation
    • 192
    • 124
    • 69
    • 40
    • 40
    • 31
    • 20
    • 17
    • 15
    • 8
    • 7
    • 6
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Homologie
    B, M, Rat
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This CDC25A Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T507 of human CDC25A.
    Klon
    RB7856
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product CDC25A Primärantikörper
  • Applikationshinweise
    IF: 1:25. WB: 1:250. WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
    Haltbarkeit
    6 months
  • Chou, Yen, Lee, Chen: "Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain." in: The Journal of biological chemistry, Vol. 285, Issue 23, pp. 17833-45, (2010) (PubMed).

    Kasahara, Goto, Enomoto, Tomono, Kiyono, Inagaki: "14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage." in: The EMBO journal, Vol. 29, Issue 16, pp. 2802-12, (2010) (PubMed).

  • Target
    CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))
    Andere Bezeichnung
    CDC25A (CDC25A Produkte)
    Synonyme
    cdc25a2 antikoerper, cdc25A antikoerper, sb:cb317 antikoerper, CDC25A2 antikoerper, D9Ertd393e antikoerper, cell division cycle 25A antikoerper, cell division cycle 25B antikoerper, cell division cycle 25A S homeolog antikoerper, CDC25A antikoerper, cdc25a antikoerper, cdc25b antikoerper, Cdc25a antikoerper, cdc25a.S antikoerper
    Hintergrund
    CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.
    Molekulargewicht
    59087
    NCBI Accession
    NP_001780, NP_963861
    UniProt
    P30304
    Pathways
    Zellzyklus, Mitotic G1-G1/S Phases, M Phase
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