BMPR2 Antikörper (N-Term)

Produktnummer ABIN388741

Produktdetails anti-BMPR2 Antikörper

Target: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Bindungsspezifität: AA 28-59, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BMPR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This BMPR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the N-terminal region of human BMPR2.

Klon: RB01778

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit: 6 months

Referenzen für anti-BMPR2 Antikörper (ABIN388741)

Lynch, Ahsan: "Correlating the Effects of Bone Morphogenic Protein to Secreted Soluble Factors from Fibroblasts and Mesenchymal Stem Cells in Regulating Regenerative Processes In Vitro." in: Tissue engineering. Part A, (2014) (PubMed).

Srikanth, Kim, Das, Kessler: "BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells." in: Molecular cancer research : MCR, Vol. 12, Issue 2, pp. 283-94, (2014) (PubMed).

Li, Cao, Ma, Wang, Zhang, Luo, Chen, Wu, Meng, Zhang, Yuan, Ma, Huang: "Roles of miR-1-1 and miR-181c in ventricular septal defects." in: International journal of cardiology, Vol. 168, Issue 2, pp. 1441-6, (2013) (PubMed).

Zhang, Mu, Zhou, Vrijens, Roussel, Jiang, Yan: "Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors." in: Cell death & disease, Vol. 3, pp. e308, (2012) (PubMed).

Jara, Chacón, Burgos, Droguett, Valdivieso, Ortiz, Troncoso, Mezzano: "Expression of gremlin, a bone morphogenetic protein antagonist,is associated with vascular calcification in uraemia." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 24, Issue 4, pp. 1121-9, (2009) (PubMed).

Sehgal, Mukhopadhyay, Xu, Patel, Shah: "Dysfunction of Golgi tethers, SNAREs, and SNAPs in monocrotaline-induced pulmonary hypertension." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 292, Issue 6, pp. L1526-42, (2007) (PubMed).

Ramos, Lamé, Segall, Wilson: "The BMP type II receptor is located in lipid rafts, including caveolae, of pulmonary endothelium in vivo and in vitro." in: Vascular pharmacology, Vol. 44, Issue 1, pp. 50-9, (2005) (PubMed).

Details zu BMPR2

Target: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Andere Bezeichnung: BMPR2 (BMPR2 Produkte)

Synonyme: BMPR-II antikoerper, BMPR3 antikoerper, BMR2 antikoerper, BRK-3 antikoerper, PPH1 antikoerper, T-ALK antikoerper, 2610024H22Rik antikoerper, AL117858 antikoerper, AW546137 antikoerper, BB189135 antikoerper, BMP-2 antikoerper, BMPR-2 antikoerper, BMPRII antikoerper, Gm20272 antikoerper, Bmpr-II antikoerper, bmprii antikoerper, bone morphogenetic protein receptor type 2 antikoerper, bone morphogenetic protein receptor, type II b (serine/threonine kinase) antikoerper, bone morphogenetic protein receptor, type II (serine/threonine kinase) antikoerper, BMPR2 antikoerper, bmpr2b antikoerper, Bmpr2 antikoerper

Hintergrund: BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension.

Molekulargewicht: 115201

Gen-ID: 659

NCBI Accession: NP_001195

UniProt: Q13873

Pathways: Growth Factor Binding