NCAPH2 Antikörper (N-Term)

Produktnummer ABIN388692

Produktdetails anti-NCAPH2 Antikörper

Target: NCAPH2 (Non-SMC Condensin II Complex, Subunit H2 (NCAPH2))

Bindungsspezifität: AA 198-227, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCAPH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This NCAPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-227 amino acids from the N-terminal region of human NCAPH2.

Klon: RB9657

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-NCAPH2 Antikörper (ABIN388692)

Lai, Wong, Lee, Li: "Caspase-3-mediated degradation of condensin Cap-H regulates mitotic cell death." in: Cell death and differentiation, Vol. 18, Issue 6, pp. 996-1004, (2011) (PubMed).

Lisková, Susor, Pivonková, Sasková, Karabínová, Kubelka: "Detection of condensin I and II in maturing pig oocytes." in: Reproduction, fertility, and development, Vol. 22, Issue 4, pp. 644-52, (2010) (PubMed).

Details zu NCAPH2

Target: NCAPH2 (Non-SMC Condensin II Complex, Subunit H2 (NCAPH2))

Andere Bezeichnung: NCAPH2 (NCAPH2 Produkte)

Synonyme: MGC81656 antikoerper, CAPH2 antikoerper, si:dkey-202b22.2 antikoerper, non-SMC condensin II complex subunit H2 antikoerper, non-SMC condensin II complex subunit H2 L homeolog antikoerper, non-SMC condensin II complex, subunit H2 antikoerper, NCAPH2 antikoerper, ncaph2.L antikoerper, ncaph2 antikoerper, Ncaph2 antikoerper

Hintergrund: Structural maintenance of chromosomes (SMC) and non-SMC condensin proteins associate into complexes that have been implicated in the process of chromosome condensation. A crucial prerequisite for accurate segregation of replicated sister chromatids is the condensation of the chromosomes into a manageable form prior to metaphase. The condensin I complex consists of two SMC subunits, SMC2 and SMC4, and three non-SMC subunits, CAP-H, CAP-G, and CAP-D2. An alternative complex, the condensin II complex, contains alternate non-SMC subunits, CAP-G2, CAP-H2, and CAP-D3. CAP-H2 is also known as Non-SMC condensin II complex, subunit H2 (NCAPH2) or kleisin beta isoform 2. The three non-SMC subunits in the condensing complexes form a regulatory subcomplex that is required to activate the SMC ATPases and to promote mitosis-specific chromatin binding of the holocomplex. The precise individual functions of each non-SMC protein in activation remain to be determined.

Molekulargewicht: 68227

Gen-ID: 29781

NCBI Accession: NP_001171940, NP_055366, NP_689512

UniProt: Q6IBW4