KCNC1 Antikörper (pSer503)

Produktnummer ABIN372706

Produktdetails anti-KCNC1 Antikörper

Target: KCNC1 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1))

Bindungsspezifität: pSer503

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Dot Blot (DB)

Spezifität: This antibody recognizes the ~100k KCNC1 (Kv3.1) protein phosphorylated at Ser503 in Rat brain extracts.

Kreuzreaktivität (Details): Species reactivity (tested):Rat and Mouse.

Aufreinigung: Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser503 of KCNC1 conjugated to keyhole limpet hemocyanin (KLH).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Dot Blot: 1/1000. Western blot: 1/1000. Immunohistochemistry on Frozen Sections: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Referenzen für anti-KCNC1 Antikörper (ABIN372706)

Ahmed, Spikings, Zhou, Thompsett, Zhang: "Pre-hybridisation: an efficient way of suppressing endogenous biotin-binding activity inherent to biotin-streptavidin detection system." in: Journal of immunological methods, Vol. 406, pp. 143-7, (2014) (PubMed).

Gupta, Palmer, Spence, Hudson, Stephens: "Kinesin-1 (uKHC/KIF5B) is required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport." in: Traffic (Copenhagen, Denmark), Vol. 9, Issue 11, pp. 1850-66, (2008) (PubMed).

Chernova, Steinert, Guerin, Nicotera, Forsythe, Smith: "Neurite degeneration induced by heme deficiency mediated via inhibition of NMDA receptor-dependent extracellular signal-regulated kinase 1/2 activation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 32, pp. 8475-85, (2007) (PubMed).

Details zu KCNC1

Target: KCNC1 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1))

Andere Bezeichnung: KCNC1 (KCNC1 Produkte)

Synonyme: kv3.1 antikoerper, C230009H10Rik antikoerper, KShIIIB antikoerper, KV4 antikoerper, Kcr2-1 antikoerper, Kv3.1 antikoerper, NGK2 antikoerper, Shaw antikoerper, Kv4 antikoerper, NGK2-KV4 antikoerper, KV3.1 antikoerper, KCNC2 antikoerper, zgc:194940 antikoerper, zgc:194950 antikoerper, potassium voltage-gated channel subfamily C member 1 antikoerper, potassium voltage-gated channel, Shaw-related subfamily, member 1 antikoerper, potassium voltage gated channel, Shaw-related subfamily, member 1 antikoerper, potassium voltage-gated channel, Shaw-related subfamily, member 1a antikoerper, KCNC1 antikoerper, kcnc1 antikoerper, Kcnc1 antikoerper, kcnc1a antikoerper

Hintergrund: Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995, Pongs, 1999, Blaine and Ribera, 1998, Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).Synonyms: Kv4, NGK2, Potassium voltage-gated channel subfamily C member 1, Voltage-gated potassium channel subunit Kv3.1

Gen-ID: 25327

NCBI Accession: NP_036988

UniProt: P25122