ARHGEF11 Antikörper (N-Term)

Produktnummer ABIN372272

Produktdetails anti-ARHGEF11 Antikörper

Target: ARHGEF11 (rho Guanine Nucleotide Exchange Factor (GEF) 11 (ARHGEF11))

Bindungsspezifität: AA 1-50, N-Term

Reaktivität: Human, Ratte, Maus, Huhn, Affe, Rind (Kuh), Hund, Pferd, Schimpanse

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARHGEF11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody recognizes Rho Guanine Exchange Factor (GEF) 11 (ARHGEF11).

Kreuzreaktivität (Details): Species reactivity (expected):Bovine, Chimpanzee, Chicken, Dog (Canine), Horse, Monkey, Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide corresponding to a portion of the amino acids 1-50 of Human ARHGEF11.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Paraffin Sections: 10 μg/mL. Western Blot: 0.1-0.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % Sodium Azide as preservative and 0.2 % Gelatin as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu ARHGEF11

Target: ARHGEF11 (rho Guanine Nucleotide Exchange Factor (GEF) 11 (ARHGEF11))

Andere Bezeichnung: ARHGEF11 (ARHGEF11 Produkte)

Synonyme: ARHGEF11 antikoerper, GTRAP48 antikoerper, PDZ-RHOGEF antikoerper, B930073M02 antikoerper, E130307F09 antikoerper, PDZ-RhoGEF antikoerper, Prg antikoerper, RhoGEF antikoerper, mKIAA0380 antikoerper, Gtrap48 antikoerper, Rho guanine nucleotide exchange factor (GEF) 11 antikoerper, Rho guanine nucleotide exchange factor 11 antikoerper, rho guanine nucleotide exchange factor 11 antikoerper, arhgef11 antikoerper, ARHGEF11 antikoerper, Arhgef11 antikoerper, LOC511220 antikoerper

Hintergrund: ARHGEF11 (Rho guanine nucleotide exchange factor 11) acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. It exhibits transforming ability, associates with and modulates the actin cytoskeleton, regulates neurite outgrowth, and mediates activation of Rho in response to stimulation by activated Galpha12/13. Rat ARHGEF11 interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. ARHGEF11 is also thought to be involved in a pathway known to play a role in both insulin secretion and action.Synonyms: GTRAP48, KIAA0380, PDZ-RhoGEF, Rho guanine nucleotide exchange factor 11, RhoGEF glutamate transport modulator GTRAP48

Gen-ID: 9826

NCBI Accession: NP_055599

UniProt: O15085

Pathways: Neurotrophin Signalübertragung, Regulation of G-Protein Coupled Receptor Protein Signaling