STAT3 Antikörper (pTyr705)

Produktnummer ABIN361960

Produktdetails anti-STAT3 Antikörper

Target: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Bindungsspezifität: pTyr705

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STAT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: The antibody detects endogenous level of STAT3 only when phosphorylated at tyrosine 705.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Immunogen: Peptide sequence around phosphorylation site of pTyr705 (A-P-Y (p) -L-K) derived from Human STAT3. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Referenzen für anti-STAT3 Antikörper (ABIN361960)

Ma, Li, Wang, Gong, Zhang, Li, Ji, Liu, Chen, Xiang: "Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K-Akt signaling pathways." in: Regulatory peptides, Vol. 181, pp. 9-16, (2013) (PubMed).

Wang, Peng-Jiao, Yang, Chuang-Yuan, Zhao, Liu, Fei, Zhang: "PF-04691502 triggers cell cycle arrest, apoptosis and inhibits the angiogenesis in hepatocellular carcinoma cells." in: Toxicology letters, Vol. 220, Issue 2, pp. 150-6, (2013) (PubMed).

Zhang, Zhao, Xin: "Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions." in: World journal of gastroenterology : WJG, Vol. 16, Issue 5, pp. 571-7, (2010) (PubMed).

Takeichi, Sugiura, Muro, Matsumoto, Ogawa, Futamura, Kaminuma, Hashimoto, Shimoyama, Saito, Tomita: "Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, similar to that seen in the psoriatic condition." in: The Journal of investigative dermatology, Vol. 130, Issue 12, pp. 2760-7, (2010) (PubMed).

García-Prieto, González-López, Cabrera, Astudillo, Gutiérrez-Fernández, Fanjul-Fernandez, Batalla-Solís, Puente, Fueyo, López-Otín, Albaiceta: "Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10." in: PLoS ONE, Vol. 5, Issue 10, pp. e13242, (2010) (PubMed).

Ren, Li, Xiao, Yan, Yang, Wang, Guo, Wang: "Endocrine glands-derived vascular endothelial growth factor protects pancreatic cancer cells from apoptosis via upregulation of the myeloid cell leukemia-1 protein." in: Biochemical and biophysical research communications, Vol. 386, Issue 1, pp. 35-9, (2009) (PubMed).

Yuan, Qian, Shi, Lu, Li, Hu, Yu, Shen, Guo: "HER2-dependent MMP-7 expression is mediated by activated STAT3." in: Cellular signalling, Vol. 20, Issue 7, pp. 1284-91, (2008) (PubMed).

Yamaguchi, Zhu, Yu, Sasaki, Umetsu, Kidachi, Ryoyama et al.: "Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their ..." in: Cell biology international, Vol. 31, Issue 6, pp. 638-44, (2007) (PubMed).

Yamaguchi, Zhu, Yu, Sasaki, Umetsu, Kidachi, Ryoyama: "Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation." in: Toxicology, Vol. 226, Issue 2-3, pp. 131-42, (2006) (PubMed).

Details zu STAT3

Target: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Andere Bezeichnung: STAT3 (STAT3 Produkte)

Synonyme: 1110034C02Rik antikoerper, AW109958 antikoerper, Aprf antikoerper, APRF antikoerper, HIES antikoerper, Xstat3 antikoerper, aprf antikoerper, hies antikoerper, stat3 antikoerper, wu:fc15d02 antikoerper, wu:fl59g06 antikoerper, z-Stat3 antikoerper, signal transducer and activator of transcription 3 antikoerper, signal transduction and activation of transcription 3 antikoerper, signal transducer and activator of transcription 3, gene 1 L homeolog antikoerper, signal transducer and activator of transcription 3 (acute-phase response factor) antikoerper, STAT3 antikoerper, stat3 antikoerper, Stat3 antikoerper, stat3.1.L antikoerper

Hintergrund: Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes.

Molekulargewicht: 88 kDa

NCBI Accession: NP_003141

UniProt: P40763

Pathways: JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Neurotrophin Signalübertragung, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor