Function: Essential ion channel and serine/threonine-proteinkinase. Divalent cation channel permeableto calcium and magnesium. Hasa central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for thechannel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to themetabolic state of the cell. Phosphorylates annexin A1 (ANXA1) Tissue specificity: Found to be expressed in brain and skeletal muscle, with stronger signals in kidney, heart, liver and spleen Sequence similarities: In the C-terminal section, belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPKsubfamily. In the N-terminal section, belongs to the transient receptor family. LTrpC subfamily. Contains 1 alpha-type protein kinasedomain.