MAPK14 Antikörper (pThr180, pTyr182)

Produktnummer ABIN361512

Produktdetails anti-MAPK14 Antikörper

Target: MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))

Bindungsspezifität: pThr180, pTyr182

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPK14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Specific for the ~39k p38 MAPK protein phosphorylated at Thr180/Tyr182 in Western blots of C-6 glioma cells prepared with anisomycin treatment. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. The antibody has been directly testet for reactivity in Western blot with human tissue. It is anticipated that the antibody will also react with bovine, canine, chicken, mouse, non-human primates, rat and zebra fish based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

Kreuzreaktivität: Human

Homologie: bovine, canine, chicken, mouse, non-human primates, rat, zebra fish

Aufreinigung: Antigen Affinity Purified from Pooled Serum

Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr180/Tyr182 conjugated to KLH

Anwendungsinformationen

Applikationshinweise: DB: 1:1000. WB: 1:1000. IHC: 1:250-1:500.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Details zu MAPK14

Target: MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))

Andere Bezeichnung: MAPK14 (MAPK14 Produkte)

Synonyme: CSBP antikoerper, CSBP1 antikoerper, CSBP2 antikoerper, CSPB1 antikoerper, EXIP antikoerper, Mxi2 antikoerper, PRKM14 antikoerper, PRKM15 antikoerper, RK antikoerper, SAPK2A antikoerper, p38 antikoerper, p38ALPHA antikoerper, CRK1 antikoerper, Csbp1 antikoerper, Csbp2 antikoerper, Exip antikoerper, Hog antikoerper, Prkm14 antikoerper, Prkm15 antikoerper, Sapk2A antikoerper, p38Hog antikoerper, p38alpha antikoerper, p38b antikoerper, zp38b antikoerper, MAPK14 antikoerper, 186F5S antikoerper, BG:DS00797.3 antikoerper, CG7393 antikoerper, D-p38 antikoerper, D-p38 MAPK antikoerper, D-p38b antikoerper, Dm p38b antikoerper, Dmel\\CG7393 antikoerper, Dmp38b antikoerper, Dp38 antikoerper, Dp38b antikoerper, ESTS:186F5S antikoerper, Mpk34C antikoerper, anon-sts23 antikoerper, dp38b antikoerper, p38 MAPK antikoerper, p38 beta antikoerper, p38B antikoerper, p38Kb antikoerper, p38beta antikoerper, Crk1 antikoerper, p38-alpha antikoerper, p38MAPK antikoerper, p38a antikoerper, csbp antikoerper, mapk14a antikoerper, mxi2 antikoerper, sapk2 antikoerper, sapk2a antikoerper, AP22.98 antikoerper, AP22_98 antikoerper, ATMPK14 antikoerper, mitogen-activated protein kinase 14 antikoerper, SAPK2a antikoerper, MAP kinase 14A antikoerper, MAP kinase p38a antikoerper, MAPK 14A antikoerper, fk28c03 antikoerper, hm:zeh1243 antikoerper, wu:fk28c03 antikoerper, zp38a antikoerper, P38C-CRK antikoerper, mitogen-activated protein kinase 14 antikoerper, mitogen activated protein kinase 14 antikoerper, mitogen-activated protein kinase 14b antikoerper, p38b MAP kinase antikoerper, mitogen-activated protein kinase 14 S homeolog antikoerper, mitogen-activated protein kinase 14a antikoerper, CRK proto-oncogene, adaptor protein antikoerper, MAPK14 antikoerper, Mapk14 antikoerper, mapk14b antikoerper, p38b antikoerper, mapk14.S antikoerper, MPK14 antikoerper, mapk14a antikoerper, CRK antikoerper

Hintergrund: The three Mitogen-Activated Protein Kinases (MAPKs) are evolutionarily conserved protein kinases that control a vast array of cellular processes. p38 MAPK is one of these kinases and it is activated by both inflammatory cytokines and by stress (Johnson and Lapadat, 2002, Shi and Gaestel, 2002). The p38 MAPK is thought to be particularly important in diseases like asthma and autoimmunity but it also plays important roles in the stress response of the nervous system (Philip and Armstead, 2003, Ying et al., 2002). Like the other MAPKs, p38 is activated by a dual specificity kinase that phosphorylates Thr180 and Tyr182 (Lin et al., 1995). Anti-Phospho Thr180/Tyr182 p38 MAPK Western blot of HeLa cell lysates that had been treated with UV or untreated (Control) showing specific immunolabeling of the ~39k p38 MAPK protein phosphorylated at Thr180 and Tyr182 .

Molekulargewicht: '39 kDa

Gen-ID: 70496

UniProt: P70618

Pathways: MAPK Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Hepatitis C, Toll-Like Receptors Cascades, Autophagie, Thromboxane A2 Receptor Signaling, BCR Signaling, S100 Proteine