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KCNC1 Antikörper (pSer503)

KCNC1 Reaktivität: Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN361488
  • Target Alle KCNC1 Antikörper anzeigen
    KCNC1 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1))
    Bindungsspezifität
    • 17
    • 15
    • 9
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer503
    Reaktivität
    • 63
    • 18
    • 11
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 66
    • 1
    Kaninchen
    Klonalität
    • 66
    • 1
    Polyklonal
    Konjugat
    • 20
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser KCNC1 Antikörper ist unkonjugiert
    Applikation
    • 55
    • 26
    • 26
    • 25
    • 14
    • 9
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Spezifität
    Specific for the ~100k Kv3.1 voltage-gated potassium channel protein phosphorylated at Ser503.
    Kreuzreaktivität
    Maus, Ratte (Rattus)
    Aufreinigung
    Antigen Affinity Purified from Pooled Serum
    Immunogen
    Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser503 conjugated to KLH
  • Applikationshinweise
    Recommended Dilution: WB: 1:1000 IHC (frozen sections, unpublished observations): 1:1000 Quality Control: Western blots performed on each lot.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    Lagerung
    -20 °C
  • Sagi, Medrihan, George, Barney, McCabe, Greengard: "Emergence of 5-HT5A signaling in parvalbumin neurons mediates delayed antidepressant action." in: Molecular psychiatry, Vol. 25, Issue 6, pp. 1191-1201, (2020) (PubMed).

  • Target
    KCNC1 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1))
    Andere Bezeichnung
    KCNC1 (KCNC1 Produkte)
    Synonyme
    kv3.1 antikoerper, C230009H10Rik antikoerper, KShIIIB antikoerper, KV4 antikoerper, Kcr2-1 antikoerper, Kv3.1 antikoerper, NGK2 antikoerper, Shaw antikoerper, Kv4 antikoerper, NGK2-KV4 antikoerper, KV3.1 antikoerper, KCNC2 antikoerper, zgc:194940 antikoerper, zgc:194950 antikoerper, potassium voltage-gated channel subfamily C member 1 antikoerper, potassium voltage-gated channel, Shaw-related subfamily, member 1 antikoerper, potassium voltage gated channel, Shaw-related subfamily, member 1 antikoerper, potassium voltage-gated channel, Shaw-related subfamily, member 1a antikoerper, KCNC1 antikoerper, kcnc1 antikoerper, Kcnc1 antikoerper, kcnc1a antikoerper
    Hintergrund
    Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995, Pongs, 1999, Blaine and Ribera, 1998, Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).
    Molekulargewicht
    '100 kDa
    Gen-ID
    25327
    UniProt
    P25122
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