GABRB2 Antikörper (Cytoplasmic Loop)

Produktnummer ABIN361447

Produktdetails anti-GABRB2 Antikörper

Target: GABRB2 (gamma-aminobutyric Acid (GABA) A Receptor, beta 2 (GABRB2))

Bindungsspezifität: Cytoplasmic Loop

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABRB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Specific for the ~55k ß2-subunit of the GABAA receptor in Western blots.

Kreuzreaktivität: Maus, Ratte (Rattus)

Homologie: canine, human, non-human primate

Aufreinigung: Antigen Affinity Purified

Immunogen: Fusion protein from the cytoplasmic loop of the beta 2 subunit

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Referenzen für anti-GABRB2 Antikörper (ABIN361447)

Antflick, Hampson: "Modulation of glutamate release from parallel fibers by mGlu4 and pre-synaptic GABA(A) receptors." in: Journal of neurochemistry, Vol. 120, Issue 4, pp. 552-63, (2012) (PubMed).

Details zu GABRB2

Target: GABRB2 (gamma-aminobutyric Acid (GABA) A Receptor, beta 2 (GABRB2))

Andere Bezeichnung: GABRB2 (GABRB2 Produkte)

Synonyme: GABRB2 antikoerper, GARB2 antikoerper, fj59e04 antikoerper, gabaabeta2 antikoerper, wu:fj59e04 antikoerper, zgc:136311 antikoerper, GABARB antikoerper, AI834970 antikoerper, C030002O17Rik antikoerper, C030021G16Rik antikoerper, Gabrab2 antikoerper, Gabrb-2 antikoerper, gamma-aminobutyric acid type A receptor beta2 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, beta 2 antikoerper, gamma-aminobutyric acid type A receptor beta 2 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 antikoerper, GABRB2 antikoerper, gabrb2 antikoerper, Gabrb2 antikoerper

Hintergrund: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six (s, four (s and four (s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for (- and (-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a (-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different (-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003). Anti-GABAA-Receptor, (2-Subunit Western blot of 7 (g of rat cerebellum (Cb) showing specific immunolabeling of the ~55k ß2-subunit of the GABAA-R.

Molekulargewicht: '55 kDa

Gen-ID: 25451

UniProt: P63138

Pathways: Sensory Perception of Sound, Synaptic Membrane