GABRA6 Antikörper (Cytoplasmic Loop)

Produktnummer ABIN361444

Produktdetails anti-GABRA6 Antikörper

Target: GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))

Bindungsspezifität: Cytoplasmic Loop

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABRA6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Specific for the ~57k a6-subunit of the GABAA receptor in Western blots. Labeling is absent in a6-subunit knockout animals.

Kreuzreaktivität: Maus, Ratte (Rattus)

Aufreinigung: Antigen Affinity Purified

Immunogen: Fusion protein from the cytoplasmic loop of the alpha 6 subunit

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Details zu GABRA6

Target: GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))

Andere Bezeichnung: GABRA6 (GABRA6 Produkte)

Synonyme: LOC100224835 antikoerper, GABRA6 antikoerper, Gabra-6 antikoerper, alpha6 antikoerper, si:dkey-217k23.1 antikoerper, zgc:73148 antikoerper, gamma-aminobutyric acid type A receptor alpha 6 subunit antikoerper, gamma-aminobutyric acid type A receptor alpha6 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6 antikoerper, gamma-aminobutyric acid (GABA) A receptor, alpha 6a antikoerper, Gabra6 antikoerper, GABRA6 antikoerper, gabra6a antikoerper

Hintergrund: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six (s, four (s and four (s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for (- and (-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a (-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different (-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, P ltl et al., 2003). Anti-GABAA Receptor, a6-Subunit Western blot of mouse forebrain lysates from Wild Type (Control) and 6-knockout (6-K/O) animals showing specific immunolabeling of the ~57k a6-subunit of the GABAA-R. The labeling was absent from a lysate prepared from 6-knockout animals.

Molekulargewicht: '57 kDa

Gen-ID: 29708

UniProt: P30191

Pathways: Synaptic Membrane