PPM1D Antikörper (C-Term)

Produktnummer ABIN360767

Produktdetails anti-PPM1D Antikörper

Target: PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPM1D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to PPM1D.

Aufreinigung: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PPM1D.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu PPM1D

Target: PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))

Andere Bezeichnung: Protein Phosphatase 1D / PPM1D (PPM1D Produkte)

Synonyme: PP2C-DELTA antikoerper, WIP1 antikoerper, AV338790 antikoerper, Wip1 antikoerper, zgc:103518 antikoerper, ppm1d antikoerper, wu:fj44c08 antikoerper, zgc:55836 antikoerper, zgc:77316 antikoerper, protein phosphatase, Mg2+/Mn2+ dependent 1D antikoerper, protein phosphatase 1D magnesium-dependent, delta isoform antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1D antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1Db antikoerper, protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1Da antikoerper, PPM1D antikoerper, Ppm1d antikoerper, ppm1db antikoerper, ppm1d.L antikoerper, ppm1da antikoerper

Hintergrund: PPM1D is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. Expression of this PPM1D gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negativelyregulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stressinduced apoptosis. The PPM1D gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.Synonyms: PP2C-delta, Protein phosphatase 2C isoform delta, Protein phosphatase magnesium-dependent 1 delta, WIP1, p53-induced protein phosphatase 1

Gen-ID: 8493, 9606

UniProt: O15297

Pathways: p53 Signalweg, Zellzyklus