PTPRA Antikörper (N-Term)

Produktnummer ABIN360736

Produktdetails anti-PTPRA Antikörper

Target: PTPRA (Protein tyrosine Phosphatase, Receptor Type, A (PTPRA))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTPRA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to PTPalpha.

Aufreinigung: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PTPalpha.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu PTPRA

Target: PTPRA (Protein tyrosine Phosphatase, Receptor Type, A (PTPRA))

Andere Bezeichnung: PTPRA (PTPRA Produkte)

Synonyme: PTPRA antikoerper, heptp antikoerper, hlpr antikoerper, hptpa antikoerper, hptpalpha antikoerper, lrp antikoerper, ptpa antikoerper, ptprl2 antikoerper, r-ptp-alpha antikoerper, rptpa antikoerper, HEPTP antikoerper, HLPR antikoerper, HPTPA antikoerper, HPTPalpha antikoerper, LRP antikoerper, PTPA antikoerper, PTPRL2 antikoerper, R-PTP-alpha antikoerper, RPTPA antikoerper, Ptpa antikoerper, Ptpalpha antikoerper, Rptpalpha antikoerper, Rptra antikoerper, Rptralpha antikoerper, RPTP[a] antikoerper, zf-RPTP[a] antikoerper, ptpa-a antikoerper, protein tyrosine phosphatase, receptor type A antikoerper, protein tyrosine phosphatase, receptor type, A antikoerper, protein tyrosine phosphatase, receptor type A S homeolog antikoerper, PTPRA antikoerper, ptpra antikoerper, Ptpra antikoerper, ptpra.S antikoerper

Hintergrund: Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation ? it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.Synonyms: PTP alpha, PTPA, PTPRL2, Protein-tyrosine phosphatase alpha, R-PTP-alpha, Receptor-type tyrosine-protein phosphatase alpha

Gen-ID: 5786, 9606

UniProt: P18433