NME3 Antikörper (AA 59-88)

Produktnummer ABIN359315

Produktdetails anti-NME3 Antikörper

Target: NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3 (NME3))

Bindungsspezifität: AA 59-88

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NME3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody recognizes NME3.

Aufreinigung: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59~88 from the center region of Human NME3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu NME3

Target: NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3 (NME3))

Andere Bezeichnung: NME3 (NME3 Produkte)

Synonyme: DR-nm23 antikoerper, NDPK-C antikoerper, NDPKC antikoerper, NM23-H3 antikoerper, NM23H3 antikoerper, c371H6.2 antikoerper, 1810009F08Rik antikoerper, AI413736 antikoerper, Ndk3 antikoerper, Nm23-DR antikoerper, Nm23-M3 antikoerper, NME/NM23 nucleoside diphosphate kinase 3 antikoerper, NME3 antikoerper, Nme3 antikoerper

Hintergrund: NME3 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34(+) cells. Its constitutive expression in a myeloid precursor line, which is growth-factor dependent for both proliferation and differentiation, results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death. These results appear consistent with a role for the NME3 gene in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest, a feature of blastic transformation in chronic myelogenous leukemia.Synonyms: DR-nm23, NDK 3, NDK-3, NDK3, NDP kinase 3, NDPKC, Nucleoside diphosphate kinase 3, Nucleoside diphosphate kinase C, nm23-H3

Gen-ID: 4832, 9606

UniProt: Q13232

Pathways: Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process