TRPV6 Antikörper (AA 320-370)

Produktnummer ABIN351306

Produktdetails anti-TRPV6 Antikörper

Target: TRPV6 (Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6))

Bindungsspezifität: AA 320-370

Reaktivität: Kaninchen

Wirt: Schaf

Klonalität: Polyklonal

Konjugat: Dieser TRPV6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Specific for TRPV6.

Immunogen: A synthetic peptide from aa region 320-370 of rabbit TRPV6 conjugated to an immunogenic carrier protein was used as the antigen.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu TRPV6

Target: TRPV6 (Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6))

Andere Bezeichnung: TRPV6 (TRPV6 Produkte)

Hintergrund: Function: Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
Subunit: Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5, heterotetramer.
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in duodenum, proximal jejunum, cecum, and colon. SIMILARITY: Belongs to the transient receptor family, TrpV subfamily. SIMILARITY: Contains 5 ANK repeats. Also known as: Transient receptor potential cation channel subfamily V member 6, TrpV6, Epithelial calcium channel 2, ECaC2, Calcium transport protein 1, CaT1, Trpv6 transient receptor potential cation channel, subfamily V, member 6, CaT1, Ecac2, Otrpc3.

Pathways: T-Zell Rezeptor Signalweg