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Sortilin 1 Antikörper (Cytoplasmic Domain)

SORT1 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN350865
  • Target Alle Sortilin 1 (SORT1) Antikörper anzeigen
    Sortilin 1 (SORT1)
    Bindungsspezifität
    • 16
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cytoplasmic Domain
    Reaktivität
    • 41
    • 34
    • 28
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 42
    • 7
    • 2
    Kaninchen
    Klonalität
    • 44
    • 7
    Polyklonal
    Konjugat
    • 27
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Sortilin 1 Antikörper ist unkonjugiert
    Applikation
    • 40
    • 19
    • 17
    • 13
    • 13
    • 12
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Spezifität
    Specific for Sortilin.
    Kreuzreaktivität
    Human
    Kreuzreaktivität (Details)
    Other species not yet tested.
    Aufreinigung
    IgG
    Immunogen
    A synthetic peptide from the cytoplasmic domain of human Sortilin conjugated to blue carrier protein was used as the antigen.
    Isotyp
    IgG
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  • Applikationshinweise
    IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
    Handhabung
    Avoid freeze and thaw cycles.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Sortilin 1 (SORT1)
    Andere Bezeichnung
    Sortilin (SORT1 Produkte)
    Synonyme
    SORT1 antikoerper, 19.m02079 antikoerper, gp95 antikoerper, ldlcq6 antikoerper, sortilin antikoerper, Gp95 antikoerper, LDLCQ6 antikoerper, NT3 antikoerper, 2900053A11Rik antikoerper, AI852375 antikoerper, Ntr3 antikoerper, Ntsr3 antikoerper, Nt3 antikoerper, Nts3 antikoerper, sort1 antikoerper, zgc:85953 antikoerper, sortilin 1 antikoerper, sortilin antikoerper, sortilin 1 S homeolog antikoerper, sortilin 1a antikoerper, SORT1 antikoerper, TP01_0016 antikoerper, BBOV_I002730 antikoerper, sort1.S antikoerper, Sort1 antikoerper, sort1a antikoerper
    Hintergrund
    FUNCTION: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. SUBUNIT: Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP and GM2A, LPL, PSAP and SLC2A4. Forms a complex with NGFR which binds specifically to the precursor form of NGFB (proNGFB). Interacts with the precursor form of BDNF (proBDNF). SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein. Note: Localized to membranes of the endosomes, Golgi stack, lysosomes and nucleus. Localization to the plasma membrane in adipocytes is enhanced by insulin. Localized to the endoplasmic reticulum and the plasma membrane. Also found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. TISSUE SPECIFICITY: Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver.,Neurogenesis,Neurotensin receptor 3, NTR3, NT3, Glycoprotein 95, Gp95, 100 kDa NT receptor
    UniProt
    Q99523
    Pathways
    Neurotrophin Signalübertragung
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