PTK7 Antikörper (N-Term)

Produktnummer ABIN318893

Produktdetails anti-PTK7 Antikörper

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTK7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody recognises Protein tyrosine kinase-like 7 (PTK7).

Aufreinigung: Antisera to human PTK7 (NT) were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Immunogen: A 15 amino acid peptide located near the N-terminal region of human PTK7.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 0.5 - 1.0g/mL, detects a band of approximately 86 kDa in colon tissuelysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PTK7

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Andere Bezeichnung: PTK7 / CCK4 (PTK7 Produkte)

Synonyme: PTK7 antikoerper, CCK-4 antikoerper, CCK4 antikoerper, Srf antikoerper, 8430404F20Rik antikoerper, chz antikoerper, mPTK7/CCK4 antikoerper, KLG antikoerper, protein tyrosine kinase 7 (inactive) antikoerper, protein tyrosine kinase 7 antikoerper, PTK7 protein tyrosine kinase 7 antikoerper, PTK7 antikoerper, Ptk7 antikoerper

Hintergrund: PTK7 is a member of the receptor tyrosine kinase family, otherwise known as Colon Carcinoma Kinase 4 (CCK4). PTK7 is highly expressed in the kidney, liver, lung, pancreas and melanocytes with weaker expression being detected in the thyroid gland, ovaries, brain, heart and skeletal muscle. PTK7 may play a role in embryonic development. It is thought to function as a cell adhesion molecule and as a novel regulator of the planar cell polarity (PCP) pathway in vertebrates. Studies also suggest that PTK7 may be involved in the tumour progression. A loss of PTK7 expression has been observed in melanoma cell lines, whereas increased levels of PTK7 have been detected in high-throughput acute myeloid leukaemia samples. In addition, PTK7 is not expressed in normal colon but has been detected in colon carcinomas and as such is a potential marker for tumour progression.Synonyms: CCK-4, Colon carcinoma kinase 4, Tyrosine-protein kinase-like 7

Gen-ID: 5754

NCBI Accession: NP_002812

UniProt: Q13308

Pathways: RTK Signalweg, Tube Formation