HRK Antikörper (Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain)) (Middle Region)

Details for Product anti-HRK Antibody No. ABIN318751
Antigen
  • DP5
  • HARAKIRI
  • AI838259
  • Bid3
  • harakiri
  • Dp5
  • harakiri, BCL2 interacting protein
  • harakiri, BCL2 interacting protein (contains only BH3 domain)
  • HRK
  • Hrk
Epitop
Middle Region
14
9
3
3
2
2
2
1
Reaktivität
Human, Maus, Ratte (Rattus)
55
16
8
2
2
2
1
Wirt
Kaninchen
55
Klonalität
Polyklonal
Konjugat
Dieser HRK Antikörper ist unkonjugiert
4
3
2
2
2
2
1
1
1
1
1
1
Applikation
Western Blotting (WB)
25
25
19
5
1
Optionen
Immunogen 15 amino acid peptide from near the centre of human HRK (NP_003797).
Isotyp IgG
Spezifität This antibody detects Harakiri (HRK), also known as DP5.
Reinigung Purified
Plasmids, Primers & others Plasmide, Primers & weitere HRK products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Harakiri / HRK (HRK Antibody Abstract)
Hintergrund HRK is a BH3 only protein of the Bcl-2 family, which promotes Bax dependent apoptosis. HRK regulates apoptosis through its interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL, and in conjunction to the mitochondrial pore forming protein p32. HRK is thought to have a specific role in initiating neuronal and haematopoietic cell apoptosis, in particular to growth factor deprivation. Aberrant methylation of HRK is frequently detected in primary colorectal cancers. Despite its predicted molecular weight, HRK often migrates at 12-15kD.Synonyms: Activator of apoptosis harakiri, BH3-interacting domain-containing protein 3, BID3, Neuronal death protein DP5
Gen-ID 8739
NCBI Accession NP_003797
UniProt O00198
Applikations-hinweise Western Blot: 2 - 5g/mL, detects a band of approximately 13 kDa in mouse pancreas tissuelysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1.0 mg/mL
Vorsichtsmaßnahmen This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
 image for anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) (Middle Region) antibody (ABIN318751) anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) (Middle Region) antibody
Allgemeine Veröffentlichungen Nakamura, Ishida, Shimada, Nakase, Sakaki, Konishi: "Frequent HRK inactivation associated with low apoptotic index in secondary glioblastomas." in: Acta neuropathologica, Vol. 110, Issue 4, pp. 402-10, 2005 (PubMed).

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