HRK Antikörper (Middle Region)

Produktnummer ABIN318751

Produktdetails anti-HRK Antikörper

Target: HRK (Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HRK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects Harakiri (HRK), also known as DP5.

Aufreinigung: Purified

Immunogen: 15 amino acid peptide from near the centre of human HRK (NP_003797).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 2 - 5g/mL, detects a band of approximately 13 kDa in mouse pancreas tissuelysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Vorsichtsmaßnahmen: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu HRK

Target: HRK (Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK))

Andere Bezeichnung: Harakiri / HRK (HRK Produkte)

Synonyme: DP5 antikoerper, HARAKIRI antikoerper, AI838259 antikoerper, Bid3 antikoerper, harakiri antikoerper, Dp5 antikoerper, harakiri, BCL2 interacting protein antikoerper, harakiri, BCL2 interacting protein (contains only BH3 domain) antikoerper, HRK antikoerper, Hrk antikoerper

Hintergrund: HRK is a BH3 only protein of the Bcl-2 family, which promotes Bax dependent apoptosis. HRK regulates apoptosis through its interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL, and in conjunction to the mitochondrial pore forming protein p32. HRK is thought to have a specific role in initiating neuronal and haematopoietic cell apoptosis, in particular to growth factor deprivation. Aberrant methylation of HRK is frequently detected in primary colorectal cancers. Despite its predicted molecular weight, HRK often migrates at 12-15kD.Synonyms: Activator of apoptosis harakiri, BH3-interacting domain-containing protein 3, BID3, Neuronal death protein DP5

Gen-ID: 8739

NCBI Accession: NP_003797

UniProt: O00198