CLCN6 Antikörper

Produktnummer ABIN317827

Produktdetails anti-CLCN6 Antikörper

Target: CLCN6 (Chloride Channel, Voltage-Sensitive 6 (CLCN6))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLCN6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: CLC-6 antibody detects endogenous levels of CLC-6 protein.(region surrounding Lys649)

Aufreinigung: Affinity chromatography

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CLCN6

Target: CLCN6 (Chloride Channel, Voltage-Sensitive 6 (CLCN6))

Andere Bezeichnung: CLCN6 (CLCN6 Produkte)

Synonyme: CLC-6 antikoerper, AI850629 antikoerper, CLCN6 antikoerper, wu:fb95f01 antikoerper, DKFZp469B244 antikoerper, DKFZp469L0417 antikoerper, chloride voltage-gated channel 6 antikoerper, chloride channel, voltage-sensitive 6 antikoerper, chloride channel 6 antikoerper, chloride transport protein 6 antikoerper, CLCN6 antikoerper, Clcn6 antikoerper, clcn6 antikoerper, LOC579870 antikoerper

Hintergrund: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7, 3q26, 4q32, Xp22, Xp11, 1p36 and 16p13, respectively. CLC-1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC-1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC-2 is highly expressed in the epithelia of several organs including lung, which suggests CLC-2 may be a possible therapeutic target for cystic fibrosis. CLC-3 expression is particularly abundant in neuronal tissue, while CLC-4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC-5 lead to Dent's disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC-6 and CLC-7 are broadly expressed in several tissues including testes, kidney, brain and muscle.Synonyms: Chloride channel protein 6, Chloride transport protein 6, ClC-6, ClC6, KIAA0046

Molekulargewicht: approx. 90 kDa

Gen-ID: 1185

NCBI Accession: NP_001277

UniProt: P51797