GTPBP1 Antikörper

Produktnummer ABIN317811

Produktdetails anti-GTPBP1 Antikörper

Target: GTPBP1 (GTP Binding Protein 1 (GTPBP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GTPBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Spezifität: GBP1 antibody detects endogenous levels of GBP1 protein.(region surrounding Glu99)

Aufreinigung: Affinity chromatography

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GTPBP1

Target: GTPBP1 (GTP Binding Protein 1 (GTPBP1))

Andere Bezeichnung: GTP-Binding Protein 1 / GBP1 (GTPBP1 Produkte)

Synonyme: GP-1 antikoerper, GP1 antikoerper, HSPC018 antikoerper, AL022987 antikoerper, AW045683 antikoerper, C85212 antikoerper, Gtpbp antikoerper, cb858 antikoerper, wu:fb36e06 antikoerper, wu:fi39g05 antikoerper, zgc:66228 antikoerper, gtpbp1 antikoerper, GTP binding protein 1 antikoerper, GTP binding protein 1 S homeolog antikoerper, GTPBP1 antikoerper, Gtpbp1 antikoerper, gtpbp1 antikoerper, gtpbp1.S antikoerper

Hintergrund: GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage step, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by IFN-γ during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi's sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.Synonyms: Guanine nucleotide-binding protein 1, HuGBP-1, Interferon-induced guanylate-binding protein 1

Molekulargewicht: approx. 68 kDa

Gen-ID: 2633

NCBI Accession: NP_002044

UniProt: P32455