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LILRB1 Antikörper

LILRB1 Reaktivität: Human FACS, IHC (fro) Wirt: Maus Monoclonal 4F9 unconjugated
Produktnummer ABIN316937
  • Target Alle LILRB1 Antikörper anzeigen
    LILRB1 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 1 (LILRB1))
    Reaktivität
    • 64
    • 4
    • 2
    Human
    Wirt
    • 39
    • 25
    Maus
    Klonalität
    • 41
    • 23
    Monoklonal
    Konjugat
    • 28
    • 8
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LILRB1 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 27
    • 24
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    This antibody is specific for CD85j, a member of the leukocyte immunoglobulin-like receptor (LIR) family.
    Produktmerkmale
    Synonyms: LIR-3, ILT5, LIR3, HL9, Leukocyte immunoglobulin-like receptor subfamily B member 3,Leukocyte immunoglobulin-like receptor 3, Immunoglobulin-like transcript 5, Monocyteinhibitory receptor HL9, CD85 antigen-like family member A
    Aufreinigung
    Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
    Immunogen
    Monocyte derived dendritic cells
    Klon
    4F9
    Isotyp
    IgG1
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  • Applikationshinweise
    Flow Cytometry: 1/50 - 1/200. Immunohistochemistry on frozen sections: 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 0.09 % Sodium Azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch. Caution: (A full Health and Safety assessment is available upon request) This product containsSodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled bytrained staff only.
    Haltbarkeit
    12 months
  • Target
    LILRB1 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 1 (LILRB1))
    Andere Bezeichnung
    CD85j / LILRB1 (LILRB1 Produkte)
    Synonyme
    CD85J antikoerper, ILT-2 antikoerper, ILT2 antikoerper, LIR-1 antikoerper, LIR1 antikoerper, MIR-7 antikoerper, MIR7 antikoerper, leukocyte immunoglobulin like receptor B1 antikoerper, LILRB1 antikoerper
    Hintergrund
    This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. CD85j is a receptor for MHC Class I molecules and ligand binding results in inhibitory signals and down-regulation of the immune response.CD85j is expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells, T-cells and natural killer (NK) cells.Synonyms: CD85 antigen-like family member J, ILT-2, ILT2, Immunoglobulin-like transcript 2, LILR-B1, LIR-1, LIR1, Leukocyte immunoglobulin-like receptor 1, Leukocyte immunoglobulin-like receptor subfamily B member 1, MIR-7, MIR7, Monocyte/macrophage immunoglobulin-like receptor 7
    Gen-ID
    10859
    UniProt
    O75022
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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