PPAP2B Antikörper

Produktnummer ABIN306894

Produktdetails anti-PPAP2B Antikörper

Target: PPAP2B (Phosphatidic Acid Phosphatase Type 2B (PPAP2B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPAP2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human

Produktmerkmale: Lipid phosphate phosphohydrolase 3, EC 3.1.3.4 Phosphatidic acid phosphatase 2b, PAP2-beta ,PAP-2b, PAP2b, Phosphatidate phosphohydrolase type 2b, Vascular endothelial growth factor and type I collagen-inducible protein, VCIP,Phosphatidic acid phosphatase type 2 (PAP2) was originally identified as a plasma membrane enzyme that catalyses the dephosphorylation of the putative second messenger, phosphatidic acid (PA) to diacylglycerol (DG) [1]. Subsequently, multiple isoforms of PAP2 were cloned [2-5]. It was found that these enzymes dephosphorylate a number of lipid phosphates in vitro other than PA, including the potent bioactive lipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Therefore, they have been renamed lipid phosphate phosphatases (LPPs). Currently, there are four members of this family called LPP1, LPP1a, LPP2 and LPP3 [6]. S1P [7] and LPA [8] regulate the proliferation, differentiation, apoptosis and migration of cells by binding to a family of G protein-coupled receptors. Thus, EDG1/S1P1, EDG3/S1P3, EDG5/S1P2/AGR16/H218, EDG6/S1P4 and EDG8/S1P5/nrg-1 are high affinity S1P receptors [7] whereas EDG2/LPA1, EDG4/LPA2 and EDG7/LPA3 have high affinity for LPA [8]. Recently, the over-expression of LPP1 was shown to limit LPA-stimulated signalling in Rat2 fibroblasts [9] and LPA-stimulated DNA synthesis in HEK 293 cells [10]. Similarly, over-expression of LPP1, LPP1a and LPP2 attenuate S1P-signalling to the p42/p44 mitogen activated protein kinase cascade [11].

Aufreinigung: Ammonium Sulfate Precipitation

Immunogen: Rabbits were immunized with a unique peptide derived from the human lysophospholipid phosphatase 3 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This antibody can be used for Western blotting (10-15 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu PPAP2B

Target: PPAP2B (Phosphatidic Acid Phosphatase Type 2B (PPAP2B))

Andere Bezeichnung: Lyosphospholipid Phosphatase (LPP) 3 (PPAP2B Produkte)

Synonyme: Dri42 antikoerper, LPP3 antikoerper, PAP2B antikoerper, VCIP antikoerper, 1110003O22Rik antikoerper, 2610002D05Rik antikoerper, AV025606 antikoerper, D4Bwg0538e antikoerper, D4Bwg1535e antikoerper, Lpp3 antikoerper, Ppab2b antikoerper, dri42 antikoerper, lpp3 antikoerper, pap2b antikoerper, ppap2bb antikoerper, vcip antikoerper, ppap2b antikoerper, ppap2ba antikoerper, PPAP2B antikoerper, si:dkey-19f4.1 antikoerper, phospholipid phosphatase 3 antikoerper, phospholipid phosphatase 3 L homeolog antikoerper, phospholipid phosphatase 3 S homeolog antikoerper, PLPP3 antikoerper, Plpp3 antikoerper, plpp3.L antikoerper, plpp3.S antikoerper, plpp3 antikoerper