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RIT2 Antikörper

RIT2 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN306807
  • Target Alle RIT2 Antikörper anzeigen
    RIT2 (Ras-Like Without CAAX 2 (RIT2))
    Reaktivität
    • 30
    • 3
    • 2
    • 1
    • 1
    Human
    Wirt
    • 22
    • 8
    Kaninchen
    Klonalität
    • 24
    • 6
    Polyklonal
    Konjugat
    • 16
    • 4
    • 3
    • 3
    • 2
    • 2
    Dieser RIT2 Antikörper ist unkonjugiert
    Applikation
    • 25
    • 19
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Kreuzreaktivität
    Human
    Produktmerkmale
    Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64 % amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100 % conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.
    Aufreinigung
    Ammonium Sulfate Precipitation
    Immunogen
    His-tagged recombinant human Rin protein
    Isotyp
    IgG
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  • Applikationshinweise
    Antibody detects recombinant Rin protein expressed in HEK-293 cells by Western blot analysis. Shows minimal cross-reactivity with Rit protein and other Ras proteins. Optimal concentration should be evaluated by serial dilutions.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Provided as solution in phosphate buffered saline with 0.08 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
  • Target
    RIT2 (Ras-Like Without CAAX 2 (RIT2))
    Andere Bezeichnung
    Rin (RIT2 Produkte)
    Synonyme
    RIBA antikoerper, RIN antikoerper, ROC2 antikoerper, Rin antikoerper, Rit1 antikoerper, Roc2 antikoerper, RIT2 antikoerper, Ras like without CAAX 2 antikoerper, Ras-like without CAAX 2 antikoerper, RIT2 antikoerper, Rit2 antikoerper
    UniProt
    Q13671
    Pathways
    Neurotrophin Signalübertragung
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