GZMA Antikörper (Middle Region)
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- Target Alle GZMA Antikörper anzeigen
- GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))
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Bindungsspezifität
- AA 175-190, Middle Region
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser GZMA Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Verwendungszweck
- Rabbit IgG polyclonal antibody for Granzyme A(GZMA) detection. Tested with WB, IHC-P in Human.
- Sequenz
- DRKVCNDRNH YNFNPV
- Kreuzreaktivität (Details)
- No cross reactivity with other proteins.
- Produktmerkmale
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Rabbit IgG polyclonal antibody for Granzyme A(GZMA) detection. Tested with WB, IHC-P in Human.
Gene Name: granzyme A(granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Protein Name: Granzyme A - Aufreinigung
- Immunogen affinity purified.
- Immunogen
- A synthetic peptide corresponding to a sequence in the middle region of human Granzyme A(175-190aa DRKVCNDRNHYNFNPV).
- Isotyp
- IgG
- Top Product
- Discover our top product GZMA Primärantikörper
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- Applikationshinweise
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users. - Kommentare
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Konzentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- Konservierungsmittel
- Thimerosal (Merthiolate), Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing. - Haltbarkeit
- 12 months
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- Target
- GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))
- Andere Bezeichnung
- GZMA (GZMA Produkte)
- Synonyme
- gzmA antikoerper, GZMA antikoerper, AW494114 antikoerper, Ctla-3 antikoerper, Ctla3 antikoerper, Hf antikoerper, SE1 antikoerper, TSP-1 antikoerper, TSP1 antikoerper, CTLA3 antikoerper, HFSP antikoerper, granzyme A antikoerper, Granzyme A antikoerper, granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) antikoerper, gzmA antikoerper, GZMA antikoerper, graa antikoerper, Gzma antikoerper
- Hintergrund
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Granzyme A is a protein that in humans is encoded by the GZMA gene. Cytolytic T lymphocytes(CTL) and natural killer(NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are though to protect their host by lysing cells bearing on their surface "nonself" antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. GZMA induces caspase-independent apoptosis in a characteristic manner, except it causes a distinctive form of DNA damage: single-stranded DNA nicking. A target of GZMA is the SET complex, including HMGB2 and ANP32A .
Synonyms: CTL tryptase antibody|CTLA3 antibody|Cytolytic t cell and natural killer cell specific trypsin like serine protease antibody|Cytotoxic T lymphocyte associated serine esterase 3 antibody|Cytotoxic T lymphocyte proteinase 1 antibody|Cytotoxic T-lymphocyte proteinase 1 antibody|Fragmentin 1 antibody|Fragmentin-1 antibody|GRAA_HUMAN antibody|Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3 antibody|Granzyme A(Cytotoxic T lymphocyte associated serine esterase 3, Hanukah factor serine protease) antibody|Granzyme A(granzyme 1, cytotoxic T lymphocyte associated serine esterase 3) antibody|Granzyme A antibody|Granzyme A precursor antibody|Granzyme-1 antibody|GZMA antibody|H factor antibody|Hanukah factor serine protease antibody|Hanukkah factor antibody|HF antibody|HFSP antibody|TSP1 antibody - UniProt
- P12544
- Pathways
- Apoptose
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