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GAD65 Antikörper (N-Term)

GAD2 Reaktivität: Human, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3044396
  • Target Alle GAD65 (GAD2) Antikörper anzeigen
    GAD65 (GAD2) (Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2))
    Bindungsspezifität
    • 16
    • 10
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 21-37, N-Term
    Reaktivität
    • 94
    • 68
    • 41
    • 16
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte
    Wirt
    • 92
    • 27
    • 1
    Kaninchen
    Klonalität
    • 95
    • 25
    Polyklonal
    Konjugat
    • 62
    • 13
    • 12
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser GAD65 Antikörper ist unkonjugiert
    Applikation
    • 102
    • 43
    • 40
    • 21
    • 17
    • 17
    • 14
    • 13
    • 13
    • 13
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Verwendungszweck
    Rabbit IgG polyclonal antibody for Glutamate decarboxylase 2(GAD2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Sequenz
    ENPGTARAWC QVAQKFT
    Kreuzreaktivität (Details)
    Predicted Cross Reactivity: mouse
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Glutamate decarboxylase 2(GAD2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: glutamate decarboxylase 2(pancreatic islets and brain, 65 kDa)
    Protein Name: Glutamate decarboxylase 2
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminus of human GAD65(21-37aa ENPGTARAWCQVAQKFT), identical to the related mouse and rat sequences.
    Isotyp
    IgG
    Top Product
    Discover our top product GAD2 Primärantikörper
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Rat, Predicted Species: Human, Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Konservierungsmittel
    Thimerosal (Merthiolate), Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Haltbarkeit
    12 months
  • Tian, Ma, Shi, Lou, Liu, Li: "Acrylamide neurotoxicity on the cerebrum of weaning rats." in: Neural regeneration research, Vol. 10, Issue 6, pp. 938-43, (2015) (PubMed).

    Shi, Ma, Zheng, Ruan, Liu, Tian, Zhang, He, Li: "Effect of sub-acute exposure to acrylamide on GABAergic neurons and astrocytes in weaning rat cerebellum." in: Toxicology and industrial health, Vol. 28, Issue 1, pp. 10-20, (2012) (PubMed).

  • Target
    GAD65 (GAD2) (Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2))
    Andere Bezeichnung
    GAD2 (GAD2 Produkte)
    Synonyme
    GAD65 antikoerper, gad65 antikoerper, F12P19.12 antikoerper, F12P19_12 antikoerper, GLUTAMATE DECARBOXYLASE 2 antikoerper, glutamate decarboxylase 2 antikoerper, zgc:112198 antikoerper, 6330404F12Rik antikoerper, GAD(65) antikoerper, Gad-2 antikoerper, glutamate decarboxylase 2 antikoerper, glutamate decarboxylase 1 antikoerper, glutamic acid decarboxylase 2 antikoerper, GAD2 antikoerper, PTRG_06148 antikoerper, LOC9324534 antikoerper, Gad2 antikoerper, GAD1 antikoerper, gad2 antikoerper
    Hintergrund
    Glutamate decarboxylase 2, also known as GAD65, is an enzyme that in humans is encoded by the GAD2 gene. This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

    Synonyms: 65 kDa glutamic acid decarboxylase antibody|DCE 2 antibody|DCE2 antibody|DCE2_HUMAN antibody|GAD 2 antibody|GAD 65 antibody|GAD-2 antibody|GAD-65 antibody|Gad2 antibody|Glutamate decarboxylase 2(pancreas) antibody|Glutamate Decarboxylase 2(pancreatic islets and brain 65 kDa) antibody|Glutamate decarboxylase 2 antibody|Glutamate Decarboxylase 65 antibody|Glutamate decarboxylase 65 kDa isoform antibody|Glutamic Acid Decarboxylase 2 antibody|Glutamic Acid Decarboxylase 65 antibody|MGC161605 antibody|MGC161607 antibody
    UniProt
    Q05329
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