APP Antikörper (Amyloid beta (A4) Precursor Protein) (AA 18-32)

Details for Product anti-APP Antibody No. ABIN3044384, Anbieter: Anmelden zum Anzeigen
Antigen
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
  • amyloid beta precursor protein
  • amyloid beta (A4) precursor protein
  • beta amyloid protein precursor-like
  • amyloid beta (A4) precursor protein a
  • amyloid beta precursor protein L homeolog
  • APP
  • app
  • Appl
  • App
  • appa
  • app.L
Epitop
AA 18-32, N-Term
106
101
70
39
37
32
31
19
17
15
15
14
14
13
12
10
9
7
7
7
7
6
6
6
5
5
5
5
5
5
5
5
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Ratte (Rattus)
931
383
362
40
27
22
19
18
15
13
12
10
7
7
4
4
4
3
2
2
1
Wirt
Kaninchen
646
261
51
7
2
Klonalität
Polyklonal
Konjugat
Dieser APP Antikörper ist unkonjugiert
51
43
41
17
16
14
14
14
13
13
13
13
13
13
13
8
8
4
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
668
405
293
159
158
122
82
57
40
36
17
15
15
10
8
3
3
2
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Verwendungszweck Rabbit IgG polyclonal antibody for Amyloid beta A4 protein(APP) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of human APP (18-32aa EVPTDGNAGLLAEPQ), identical to the related mouse and rat sequences.
Sequenz EVPTDGNAGL LAEPQ
Isotyp IgG
Kreuzreaktivität (Details) Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
Produktmerkmale Rabbit IgG polyclonal antibody for Amyloid beta A4 protein(APP) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: amyloid beta(A4) precursor protein
Protein Name: Amyloid beta A4 protein
Reinigung Immunogen affinity purified.
Andere Bezeichnung APP (APP Antibody Abstract)
Hintergrund Amyloid precursor protein(APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and iron export. APP is best known and most commonly studied as the precursor molecule whose proteolysis generates beta amyloid(Abeta), a 39- to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. APP undergoes posttranslational proteolytic processing by alpha-, beta-, and gamma-secretases. Alpha-secretase generates soluble amyloid protein, while beta- and gamma-secretases generate APP components with amyloidogenic features. These 2 processing pathways are mutually exclusive.

Synonyms: A4 amyloid protein antibody|A4 antibody|A4_HUMAN antibody|AAA antibody|ABETA antibody|ABPP antibody|AD 1 antibody|AD1 antibody|AICD-50 antibody|AICD-57 antibody|AICD-59 antibody|AID(50) antibody|AID(57) antibody|AID(59) antibody|Alzheimer Disease 1 antibody|Alzheimer disease amyloid protein antibody|Alzheimer's Disease Amyloid Protein antibody|Amyloid beta(A4) precursor protein antibody|Amyloid beta A4 protein antibody|Amyloid Beta A4 Protein Precursor Isoform A antibody|Amyloid beta A4 protein precursor isoform b antibody|Amyloid beta A4 protein precursor isoform c antibody|Amyloid Beta Peptide antibody|Amyloid beta protein antibody|Amyloid intracellular domain 50 antibody|Amyloid intracellular domain 57 antibody|Amyloid intracellular domain 59 antibody|Amyloid Of Aging And Alzheimer Disease antibody|APP antibody|APPI antibody|Beta amyloid peptide antibody|Beta-APP40 antibody|Beta-APP42 antibody|C31 antibody|Cerebal Vascular Amyloid Peptide antibody|Cerebral vascular amyloid peptide antibody|CTFgamma antibody|CVAP antibody|Gamma-CTF(50) antibody|Gamma-CTF(57) antibody|Gamma-CTF(59) antibody|Human mRNA For Amyloid A4 Precursor Of Alzheimer's Disease antibody|Peptidase nexin II antibody|peptidase nexin-II antibody|PN 2 antibody|PN II antibody|PN-II antibody|PN2 antibody|PNII antibody|PREA4 antibody|Protease Nexin II antibody|Protease nexin-II antibody|S-APP-alpha antibody|S-APP-beta antibody
UniProt P05067
Pathways Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
Applikationshinweise WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Kommentare

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Konzentration 500 μg/mL
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Konservierungsmittel Thimerosal (Merthiolate), Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Haltbarkeit 12 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Amyloid beta (A4) Precursor Protein (APP) (AA 18-32), (N-Term) antibody (ABIN3044384) Anti-Amyloid beta precursor protein antibody, Western blotting All lanes: Anti Amyloi...
Immunohistochemistry (IHC) image for anti-Amyloid beta (A4) Precursor Protein (APP) (AA 18-32), (N-Term) antibody (ABIN3044384) Anti-Amyloid beta precursor protein antibody, IHC(P) IHC(P): Rat Brain Tissue
Produkt verwendet in: Sun, Zhou, Yi, Jiang, Yuan: "Lead-induced morphological changes and amyloid precursor protein accumulation in adult rat hippocampus." in: Biotechnic & histochemistry : official publication of the Biological Stain Commission, Vol. 89, Issue 7, pp. 513-7, 2014 (PubMed).

Qin, Yao, Huang: "Effects of compound danshen tablets on spatial cognition and expression of brain beta-amyloid precursor protein in a rat model of Alzheimer's disease." in: Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine, Vol. 32, Issue 1, pp. 63-6, 2012 (PubMed).

Li, Li, Huang, Kan, Wang, Wu, Yin, Yao: "Dexamethasone and A???-?? accelerate learning and memory impairments due to elevate amyloid precursor protein expression and neuronal apoptosis in 12-month male rats." in: Behavioural brain research, Vol. 227, Issue 1, pp. 142-9, 2011 (PubMed).

Nie, Luo, Huang, Gong, Wu, Shi: "Icariin inhibits beta-amyloid peptide segment 25-35 induced expression of beta-secretase in rat hippocampus." in: European journal of pharmacology, Vol. 626, Issue 2-3, pp. 213-8, 2009 (PubMed).

Haben Sie etwas anderes gesucht?