HLA-DMB Antikörper (Middle Region)
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- Target Alle HLA-DMB Antikörper anzeigen
- HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))
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Bindungsspezifität
- AA 81-100, Middle Region
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser HLA-DMB Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Verwendungszweck
- Rabbit IgG polyclonal antibody for HLA class II histocompatibility antigen, DM beta chain(HLA-DMB) detection. Tested with WB, IHC-P in Human.
- Sequenz
- NQKDTLMQRL RNGLQNCATH
- Kreuzreaktivität (Details)
- No cross reactivity with other proteins.
- Produktmerkmale
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Rabbit IgG polyclonal antibody for HLA class II histocompatibility antigen, DM beta chain(HLA-DMB) detection. Tested with WB, IHC-P in Human.
Gene Name: major histocompatibility complex, class II, DM beta
Protein Name: HLA class II histocompatibility antigen, DM beta chain - Aufreinigung
- Immunogen affinity purified.
- Immunogen
- A synthetic peptide corresponding to a sequence in the middle region of human HLA DMB(81-100aa NQKDTLMQRLRNGLQNCATH).
- Isotyp
- IgG
- Top Product
- Discover our top product HLA-DMB Primärantikörper
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- Applikationshinweise
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users. - Kommentare
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Konzentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- Konservierungsmittel
- Thimerosal (Merthiolate), Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing. - Haltbarkeit
- 12 months
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- Target
- HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))
- Andere Bezeichnung
- HLA-DMB (HLA-DMB Produkte)
- Synonyme
- RING7 antikoerper, D6S221E antikoerper, RT1.DMb antikoerper, RT1.Mb antikoerper, MHC-DMB antikoerper, major histocompatibility complex, class II, DM beta antikoerper, RT1 class II, locus DMb antikoerper, HLA-DMB antikoerper, RT1-DMb antikoerper, PATR-DMB antikoerper
- Hintergrund
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HLA-DMB(major histocompatibility complex, class II, DM beta), also known as D6S221E, RING7, HLA-DM histocompatibility type, beta chain, HLADMB or RING7, is a protein that in humans is encoded by the HLA-DMB gene. The HLA-DMB gene is mapped on 6p21.32. HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha(DMA) and a beta(DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP(class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. HLA-DMA and -DMB appear to encode subunits of a functional heterodimer that is critical in the pathway of class II antigen presentation.
Synonyms: class II antigen HLA-DM beta chain antibody|class II histocompatibility antigen antibody|Class II histocompatibility antigen M beta chain antibody|D6S221E antibody|DMB antibody|HLA class II histocompatibility antigen DM beta chain antibody|HLA-DM histocompatibility type, beta chain antibody|M beta chain antibody|Major histocompatibility complex class II DM beta antibody|MHC class II antigen DMB antibody|MHC class II antigen HLA DM beta chain antibody|MHC class II HLA DMB antibody|OTTHUMP00000029257 antibody|Really interesting new gene 7 protein antibody|RING 7 antibody|RING7 antibody - UniProt
- P28068
- Pathways
- Cancer Immune Checkpoints
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