CXCL1 Antikörper (C-Term)

Produktnummer ABIN3044150

Produktdetails anti-CXCL1 Antikörper

Target: CXCL1 (Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) (CXCL1))

Bindungsspezifität: AA 99-107, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Growth-regulated alpha protein(CXCL1) detection. Tested with WB in Human.

Sequenz: KMLNSDKSN

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Growth-regulated alpha protein(CXCL1) detection. Tested with WB in Human.
Gene Name: chemokine(C-X-C motif) ligand 1(melanoma growth stimulating activity, alpha)
Protein Name: Growth-regulated alpha protein

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human GRO alpha(99-107aa KMLNSDKSN).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Referenzen für anti-CXCL1 Antikörper (ABIN3044150)

Xu, Zhu, Zhang, Tian, Zhang, Wu, Gao: "NF?B-mediated CXCL1 production in spinal cord astrocytes contributes to the maintenance of bone cancer pain in mice." in: Journal of neuroinflammation, Vol. 11, pp. 38, (2014) (PubMed).

Chen, Park, Xie, Berta, Nedergaard, Ji: "Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice." in: Brain : a journal of neurology, Vol. 137, Issue Pt 8, pp. 2193-209, (2014) (PubMed).

Cao, Zhang, Xie, Jiang, Ji, Gao: "Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2." in: Experimental neurology, Vol. 261, pp. 328-36, (2014) (PubMed).

Zhang, Cao, Zhang, Ji, Gao: "Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons." in: Pain, Vol. 154, Issue 10, pp. 2185-97, (2013) (PubMed).

Details zu CXCL1

Target: CXCL1 (Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) (CXCL1))

Andere Bezeichnung: CXCL1 (CXCL1 Produkte)

Synonyme: FSP antikoerper, GRO1 antikoerper, GROa antikoerper, MGSA antikoerper, MGSA-a antikoerper, NAP-3 antikoerper, SCYB1 antikoerper, CINC-1 antikoerper, Gro1 antikoerper, CXCL1 antikoerper, Sdf1 antikoerper, Fsp antikoerper, KC antikoerper, Mgsa antikoerper, N51 antikoerper, Scyb1 antikoerper, gro antikoerper, GRO antikoerper, Gro antikoerper, C-X-C motif chemokine ligand 1 antikoerper, chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) antikoerper, C-X-C motif chemokine ligand 12 antikoerper, chemokine (C-X-C motif) ligand 1 antikoerper, CXCL1 antikoerper, Cxcl1 antikoerper, Cxcl12 antikoerper, GRO1 antikoerper

Hintergrund: CXCL1(Chemokine, CXC motif, Ligand 1), also called GRO1, SCYB1, GROA or MGSA, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROalpha, KC, Neutrophil-activating protein 3(NAP-3) and melanoma growth stimulating activity, alpha(MSGA-alpha). In humans, this protein is encoded by the CXCL1 gene. The CXCL1 gene is mapped on 4q13.3. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation,wound healing, and tumorigenesis. Signaling through Cxcr2, Cxcl1 inhibited oligodendrocyte precursor migration. The migrational arrest was rapid, reversible, and concentration dependent, and it reflected enhanced cell/substrate interactions. White matter expression of Cxcl1 was temporospatially regulated. Others contribute to aggressive growth selectivity in the lung. Among the lung metastasis signature genes identified, several, including CXCL1, were functionally validated.

Synonyms: C-X-C motif chemokine 1 antibody|Chemokine(C X C motif) ligand 1 antibody|Chemokine(C-X-C motif) ligand 1(melanoma growth stimulating activity, alpha) antibody|chemokine(C-X-C motif) ligand 1 antibody|Chemokine ligand 1 antibody|CINC-1 antibody|Cxcl 1 antibody|Cxcl1 antibody|Cytokine-induced neutrophil chemoattractant 1 antibody|Fibroblast secretory protein antibody|Fsp antibody|Gro 1 antibody|Gro A antibody|GRO alpha antibody|GRO antibody|GRO protein, alpha antibody|GRO-alpha(1-73) antibody|GRO-alpha(6-73) antibody|Gro1 antibody|GRO1 oncogene(melanoma growth stimulating activity, alpha) antibody|GRO1 oncogene(melanoma growth-stimulating activity) antibody|Gro1 oncogene antibody|GroA antibody|GROA_HUMAN antibody|Growth regulated protein alpha antibody|Growth regulated protein GRO antibody|KC antibody|KC chemokine, mouse, homolog of antibody|Melanoma growth stimulatory activity alpha antibody|Melanoma growth stimulatory activity antibody|Melanoma growth stimulatory activity, alpha antibody|MGSA a antibody|MGSA alpha antibody|MGSA antibody|MGSA-a antibody|N51 antibody|NAP 3 antibody|NAP-3 antibody|NAP3 antibody|Neutrophil activating protein 3 antibody|Neutrophil-activating protein 3 antibody|Platelet-derived growth factor-inducible protein KC antibody|Scyb 1 antibody|SCYB1 antibody|Secretory protein N51 antibody|Small inducible cytokine subfamily B, member 1 antibody

UniProt: P09341

Pathways: Autophagie