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LAT Antikörper (Linker For Activation of T Cells) (AA 242-262) Primary Antibody

LAT Reaktivität: Human ICC, IHC (p), WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043991
$280.00
Zzgl. Versandkosten $45.00
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 4 bis 6 Werktagen
  • Target
    LAT
    Bindungsspezifität
    AA 242-262, C-Term
    • 18
    • 17
    • 13
    • 9
    • 8
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Reaktivität
    Human
    • 127
    • 81
    • 78
    • 1
    Wirt
    Kaninchen
    • 113
    • 8
    • 7
    • 2
    Klonalität
    Polyklonal
    • 123
    • 7
    Konjugat
    Dieser LAT Antikörper ist unkonjugiert
    • 69
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Applikation
    Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    • 82
    • 46
    • 28
    • 16
    • 10
    • 8
    • 6
    • 5
    • 2
    • 1
    • 1
    Verwendungszweck
    Rabbit IgG polyclonal antibody for Linker for activation of T-cells family member 1(LAT) detection. Tested with WB, IHC-P, ICC in Human.
    Sequenz
    QEAEEVEEEG APDYENLQEL N
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Linker for activation of T-cells family member 1(LAT) detection. Tested with WB, IHC-P, ICC in Human.
    Gene Name: linker for activation of T cells
    Protein Name: Linker for activation of T-cells family member 1
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human LAT(242-262aa QEAEEVEEEGAPDYENLQELN), different from the related mouse and rat sequences by six amino acids.
    Isotyp
    IgG
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for LAT is approximately 0.5 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Konservierungsmittel
    Thimerosal (Merthiolate), Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Haltbarkeit
    12 months
  • Target
    LAT
    Andere Bezeichnung
    LAT (LAT Antibody Abstract)
    Synonyme
    LAT, lat, LAT1, pp36, linker for activation of T-cells, linker for activation of T cells, LAT, lat, Lat
    Hintergrund
    Linker for activation of T cells, also known as LAT, is a protein which in humans is encoded by the LAT gene. This gene is mapped to 16p11.2. The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor(TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement.

    Synonyms: 36 kDa phospho tyrosine adapter protein antibody|36 kDa phospho-tyrosine adapter protein antibody|36 kDa phospho-tyrosine adaptor protein antibody|LAT 1 antibody|lat antibody|LAT_HUMAN antibody|LAT1 antibody|Linker for activation of T cells antibody|Linker for activation of T cells family member 1 antibody|linker for activation of T cells, transmembrane adaptor antibody|Linker for activation of T-cells family member 1 antibody|p36 38 antibody|p36-38 antibody|pp36 antibody
    UniProt
    O43561
    Pathways
    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung
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