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CASP14 Antikörper (C-Term)

CASP14 Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043977
  • Target Alle CASP14 Antikörper anzeigen
    CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))
    Bindungsspezifität
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 223-242, C-Term
    Reaktivität
    • 42
    • 19
    • 18
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 40
    • 6
    • 1
    Kaninchen
    Klonalität
    • 31
    • 16
    Polyklonal
    Konjugat
    • 33
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser CASP14 Antikörper ist unkonjugiert
    Applikation
    • 29
    • 11
    • 8
    • 8
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Verwendungszweck
    Rabbit IgG polyclonal antibody for Inactive Caspase-14(CASP14) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Sequenz
    KARKTNPEIQ STLRKRLYLQ
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Inactive Caspase-14(CASP14) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: caspase 14, apoptosis-related cysteine peptidase
    Protein Name: Caspase-14
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human Caspase-14(223-242aa KARKTNPEIQSTLRKRLYLQ), different from the related rat and mouse sequences by four amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product CASP14 Primärantikörper
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for CASP14 is approximately 0.5 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Konservierungsmittel
    Thimerosal (Merthiolate), Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Haltbarkeit
    12 months
  • Target
    CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))
    Andere Bezeichnung
    CASP14 (CASP14 Produkte)
    Synonyme
    CASP14 antikoerper, MICE antikoerper, mini-ICE antikoerper, caspase 14, apoptosis-related cysteine peptidase antikoerper, caspase 14 antikoerper, caspase-14-like antikoerper, caspase-14 antikoerper, CASP14 antikoerper, Casp14 antikoerper, LOC485601 antikoerper, LOC780455 antikoerper
    Hintergrund
    Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene. CASP14 belongs the evolutionarily conserved caspase family. CASP14 was assigned to chromosome 19p13.1. Using Northern blot and semiquantitative RT-PCR analyses, it was showed that CASP14 was transcriptionally upregulated during maintenance of confluent cultures of human epidermal keratinocytes. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. Caspase 14 seems to play a role in keratinocyte differentiation and cornification and probably regulates maturation of the epidermis by proteolytically processing filaggrin.

    Synonyms: Apoptosis related cysteine protease antibody|CASP 14 antibody|CASP-14 antibody|CASP14 antibody|Caspase 14 apoptosis related cysteine protease antibody|Caspase 14 precursor antibody|Caspase-14 subunit p10 antibody|Caspase14 antibody|CASPE_HUMAN antibody|MGC119078 antibody|MGC119079 antibody|MICE antibody|Mini ICE antibody
    UniProt
    P31944
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