RALB Antikörper (C-Term)

Produktnummer ABIN3043919

Produktdetails anti-RALB Antikörper

Target: RALB (Ralb) (V-Ral Simian Leukemia Viral Oncogene Homolog B (Ras Related, GTP Binding Protein) (Ralb))

Bindungsspezifität: AA 166-203, C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RALB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Ras-related protein Ral-B(RALB) detection. Tested with WB in Human,Mouse,Rat.

Sequenz: DKVFFDLMRE IRTKKMSENK DKNGKKSSKN KKSFKERC

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Ras-related protein Ral-B(RALB) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: v-ral simian leukemia viral oncogene homolog B
Protein Name: Ras-related protein Ral-B

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human RALB (166-203aa DKVFFDLMREIRTKKMSENKDKNGKKSSKNKKSFKERC), different from the related mouse sequence by three amino acids, and from the related rat sequence by four amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu RALB

Target: RALB (Ralb) (V-Ral Simian Leukemia Viral Oncogene Homolog B (Ras Related, GTP Binding Protein) (Ralb))

Andere Bezeichnung: RALB (Ralb Produkte)

Synonyme: dRalb antikoerper, 5730472O18Rik antikoerper, Ral B antikoerper, ralb antikoerper, xralb antikoerper, zgc:100801 antikoerper, KRAS2 antikoerper, k-ras antikoerper, RAS like proto-oncogene B antikoerper, v-ral simian leukemia viral oncogene B antikoerper, v-ral simian leukemia viral oncogene homolog B L homeolog antikoerper, v-ral simian leukemia viral oncogene homolog Ba (ras related) antikoerper, v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) antikoerper, RALB antikoerper, Ralb antikoerper, ralb.L antikoerper, ralba antikoerper, ralb antikoerper

Hintergrund: Ras-related protein Ral-B (RalB) is a protein that in humans is encoded by the RALB gene on chromosome 2. This protein is one of two isoforms of the Ral protein, the other being RalA, and part of the Ras GTPase family. As a Ras GTPase, RalB functions as a molecular switch that becomes active when bound to GTP and inactive when bound to GDP. RalB can be activated by RalGEFs and, in turn, activate effectors in signal transduction pathways leading to biological outcomes. Additionally, Ral proteins have been associated with the progression of several cancers, including bladder cancer and prostate cancer. While the above functions appear to be shared between the two Ral isoforms, their differential subcellular localizations result in their differing involvement in certain biological processes. In particular, RalB is more involved in apoptosis and cell motility. Moreover, RalB specifically interacts with Exo84 to assemble the beclin-1-VPS34 autophagy initiation complex, and with Sec5 to activate the innate immune response via the Tank-binding kinase 1 (TBK1).

Synonyms: 5730472O18Rik antibody|dRalb antibody|GTP binding protein antibody|Ralb antibody|RALB_HUMAN antibody|RAS like protein B antibody|Ras related GTP binding protein B antibody|Ras-related protein Ral-B antibody|v ral simian leukemia viral oncogene homolog B (ras related GTP binding protein) antibody|v ral simian leukemia viral oncogene homolog B (ras related) antibody|V ral simian leukemia viral oncogene homolog B antibody

Gen-ID: 5899

UniProt: P11234

Pathways: Neurotrophin Signalübertragung, CXCR4-mediated Signaling Events